{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zhang Y"],"funding":["Hong Zhou"],"pagination":["124"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10227983"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["21(1)"],"pubmed_abstract":["It is unclear whether membrane vitamin D receptor (mVDR) exists on the macrophage membrane or whether mVDR is associated with lipopolysaccharide (LPS) tolerance. Herein, we report that interfering with caveolae and caveolae-dependent lipid rafts inhibited the formation of LPS tolerance. VDR was detected as co-localized with membrane molecular markers. VDR was detected on the cell membrane and its level was higher in LPS-tolerant cells than that in only LPS treatment cells. Anti-VDR antibodies could abolish the effect of artesunate (AS) to reverse LPS tolerance, and the wild-type peptides (H397 and H305) of VDR, but not the mutant peptide (H397D and H305A), led to the loss of AS's effect. AS decreased the mVDR level in LPS-tolerant cells. In vivo, AS significantly reduced VDR level in the l"],"journal":["Cell communication and signaling : CCS"],"pubmed_title":["Vitamin D receptor (VDR) on the cell membrane of mouse macrophages participates in the formation of lipopolysaccharide tolerance: mVDR is related to the effect of artesunate to reverse LPS tolerance."],"pmcid":["PMC10227983"],"funding_grant_id":["81872914"],"pubmed_authors":["Pan X","Wu J","Zheng Y","Lu Y","Li P","Deng F","Hua L","Liu X","Wang N","Zheng J","Li X","Huang Y","Luo J","Zhang Y","Liao M","Zhou H","Zhou J","Shang S","Yuan Y"],"additional_accession":[]},"is_claimable":false,"name":"Vitamin D receptor (VDR) on the cell membrane of mouse macrophages participates in the formation of lipopolysaccharide tolerance: mVDR is related to the effect of artesunate to reverse LPS tolerance.","description":"It is unclear whether membrane vitamin D receptor (mVDR) exists on the macrophage membrane or whether mVDR is associated with lipopolysaccharide (LPS) tolerance. Herein, we report that interfering with caveolae and caveolae-dependent lipid rafts inhibited the formation of LPS tolerance. VDR was detected as co-localized with membrane molecular markers. VDR was detected on the cell membrane and its level was higher in LPS-tolerant cells than that in only LPS treatment cells. Anti-VDR antibodies could abolish the effect of artesunate (AS) to reverse LPS tolerance, and the wild-type peptides (H397 and H305) of VDR, but not the mutant peptide (H397D and H305A), led to the loss of AS's effect. AS decreased the mVDR level in LPS-tolerant cells. In vivo, AS significantly reduced VDR level in the l","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 May","modification":"2026-04-08T15:35:00.91Z","creation":"2025-02-19T03:56:10.723Z"},"accession":"S-EPMC10227983","cross_references":{"pubmed":["37248534"],"doi":["10.1186/s12964-023-01137-w"]}}