{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Basalely AM"],"funding":["NCATS NIH HHS","NIDDK NIH HHS"],"pagination":["1353-1360"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10228559"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["42(10)"],"pubmed_abstract":["<h4>Objective</h4>To determine the association of dysnatremia in the first postnatal week and risk of acute kidney injury (AKI) and mortality.<h4>Study design</h4>A secondary analysis of 1979 neonates in the AWAKEN cohort evaluated the association of dysnatremia with (1) AKI in the first postnatal week and (2) mortality, utilizing time-varying Cox proportional hazard models.<h4>Result</h4>Dysnatremia developed in 50.2% of the cohort and was not associated with AKI. Mortality was associated with hyponatremia (HR 2.15, 95% CI 1.07-4.31), hypernatremia (HR 4.23, 95% CI 2.07-8.65), and combined hypo/hypernatremia (HR 6.39, 95% CI 2.01-14.01). In stratified models by AKI-status, hypernatremia and hypo/hypernatremia increased risk of mortality in neonates without AKI.<h4>Conclusion</h4>Dysnatrem"],"journal":["Journal of perinatology : official journal of the California Perinatal Association"],"pubmed_title":["Association of early dysnatremia with mortality in the neonatal intensive care unit: results from the AWAKEN study."],"pmcid":["PMC10228559"],"funding_grant_id":["T32 DK007110","UL1 TR003096","UL1 TR002556","U54 TR001356","UL1 TR001417","UL1 TR001449"],"pubmed_authors":["Sridhar S","Goldstein S","Charlton J","Colaizy T","Gien J","Brophy P","Ray P","Mian A","Singh AJ","Jetton J","Ingraham S","Bhutada A","Griffin R","Juul S","Hanna M","Dupont T","Sarker S","AWAKEN Study Group","Ambalavanan N","Nathan A","Sethi S","Fletcher J","Duara S","Charlton JR","Gist KM","Nada A","Rademacher E","Harer M","Kupferman J","Selewski D","Hu C","Defreitas M","Revenis M","Wazir S","Mhanna M","Guillet R","Askenazi DJ","Basalely AM","Wintermark P","El Samra A","Mammen C","Selewski DT","Sethna F","Woroniecki R","Ohls R","Perrazo S","Reidy KJ","Ariken A","Rhee C","Chishti A","Wong C","D'Angio CT","Synnes A","Schwartz G","Zappitelli M","Uy N","Dubey S","Kaskel F","Kent A","Raina R","Greenberg J","Fine R","Milner L","Fuloria M","Smith A","Soranno D","Askenazi D","Gist K","Hingorani S","Klein J","Kaskel FJ","Kumar D","Nicoletta J","Yasin S","Bonachea E","Reidy K","Joseph C","Abitbol C","Rastogi S","Swanson J","Staples A"],"additional_accession":[]},"is_claimable":false,"name":"Association of early dysnatremia with mortality in the neonatal intensive care unit: results from the AWAKEN study.","description":"<h4>Objective</h4>To determine the association of dysnatremia in the first postnatal week and risk of acute kidney injury (AKI) and mortality.<h4>Study design</h4>A secondary analysis of 1979 neonates in the AWAKEN cohort evaluated the association of dysnatremia with (1) AKI in the first postnatal week and (2) mortality, utilizing time-varying Cox proportional hazard models.<h4>Result</h4>Dysnatremia developed in 50.2% of the cohort and was not associated with AKI. Mortality was associated with hyponatremia (HR 2.15, 95% CI 1.07-4.31), hypernatremia (HR 4.23, 95% CI 2.07-8.65), and combined hypo/hypernatremia (HR 6.39, 95% CI 2.01-14.01). In stratified models by AKI-status, hypernatremia and hypo/hypernatremia increased risk of mortality in neonates without AKI.<h4>Conclusion</h4>Dysnatrem","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Oct","modification":"2025-04-04T03:00:46.464Z","creation":"2025-04-04T03:00:46.464Z"},"accession":"S-EPMC10228559","cross_references":{"pubmed":["34775486"],"doi":["10.1038/s41372-021-01260-x"]}}