biostudies-literatureBasalely AMNCATS NIH HHSNIDDK NIH HHS1353-1360https://www.ebi.ac.uk/biostudies/studies/S-EPMC10228559biostudies-literatureUnknown42(10)<h4>Objective</h4>To determine the association of dysnatremia in the first postnatal week and risk of acute kidney injury (AKI) and mortality.<h4>Study design</h4>A secondary analysis of 1979 neonates in the AWAKEN cohort evaluated the association of dysnatremia with (1) AKI in the first postnatal week and (2) mortality, utilizing time-varying Cox proportional hazard models.<h4>Result</h4>Dysnatremia developed in 50.2% of the cohort and was not associated with AKI. Mortality was associated with hyponatremia (HR 2.15, 95% CI 1.07-4.31), hypernatremia (HR 4.23, 95% CI 2.07-8.65), and combined hypo/hypernatremia (HR 6.39, 95% CI 2.01-14.01). In stratified models by AKI-status, hypernatremia and hypo/hypernatremia increased risk of mortality in neonates without AKI.<h4>Conclusion</h4>DysnatremJournal of perinatology : official journal of the California Perinatal AssociationAssociation of early dysnatremia with mortality in the neonatal intensive care unit: results from the AWAKEN study.PMC10228559T32 DK007110UL1 TR003096UL1 TR002556U54 TR001356UL1 TR001417UL1 TR001449Sridhar SGoldstein SCharlton JColaizy TGien JBrophy PRay PMian ASingh AJJetton JIngraham SBhutada AGriffin RJuul SHanna MDupont TSarker SAWAKEN Study GroupAmbalavanan NNathan ASethi SFletcher JDuara SCharlton JRGist KMNada ARademacher EHarer MKupferman JSelewski DHu CDefreitas MRevenis MWazir SMhanna MGuillet RAskenazi DJBasalely AMWintermark PEl Samra AMammen CSelewski DTSethna FWoroniecki ROhls RPerrazo SReidy KJAriken ARhee CChishti AWong CD'Angio CTSynnes ASchwartz GZappitelli MUy NDubey SKaskel FKent ARaina RGreenberg JFine RMilner LFuloria MSmith ASoranno DAskenazi DGist KHingorani SKlein JKaskel FJKumar DNicoletta JYasin SBonachea EReidy KJoseph CAbitbol CRastogi SSwanson JStaples AfalseAssociation of early dysnatremia with mortality in the neonatal intensive care unit: results from the AWAKEN study.<h4>Objective</h4>To determine the association of dysnatremia in the first postnatal week and risk of acute kidney injury (AKI) and mortality.<h4>Study design</h4>A secondary analysis of 1979 neonates in the AWAKEN cohort evaluated the association of dysnatremia with (1) AKI in the first postnatal week and (2) mortality, utilizing time-varying Cox proportional hazard models.<h4>Result</h4>Dysnatremia developed in 50.2% of the cohort and was not associated with AKI. Mortality was associated with hyponatremia (HR 2.15, 95% CI 1.07-4.31), hypernatremia (HR 4.23, 95% CI 2.07-8.65), and combined hypo/hypernatremia (HR 6.39, 95% CI 2.01-14.01). In stratified models by AKI-status, hypernatremia and hypo/hypernatremia increased risk of mortality in neonates without AKI.<h4>Conclusion</h4>Dysnatrem2022-01-01T00:00:00Z2022 Oct2025-04-04T03:00:46.464Z2025-04-04T03:00:46.464ZS-EPMC102285593477548610.1038/s41372-021-01260-x