{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["15(2)"],"submitter":["Li Y"],"pubmed_abstract":["<h4>Objective</h4>To study the chemical constituents of the EtOAc extract of <i>Armillaria gallica</i> 012m.<h4>Methods</h4>The chemical constituents of the EtOAc extract of <i>A. gallica</i> 012m were isolated and purified by various column chromatography and their structures were elucidated on the basis of the 1D and 2D NMR spectroscopic and HRESIMS data. Cytotoxicity of all isolates against A549, HCT-116, M231 and W256 human tumor cells was determined by the MTT method.<h4>Results</h4>A new sesquiterpene aryl ester, armimelleolide C (<b>1</b>), and eight known ones including armillarivin (<b>2</b>), melleolide F (<b>3</b>), 6'-chloromelleolide F (<b>4</b>), melleolide (<b>5</b>), melleolide K (<b>6</b>), melledonol (<b>7</b>), 13-hydroxydihydromelleolide (<b>8</b>), and armillane (<b>9<"],"journal":["Chinese herbal medicines"],"pagination":["343-346"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10230622"],"repository":["biostudies-literature"],"pubmed_title":["Cytotoxic sesquiterpene aryl esters from <i>Armillaria gallica</i> 012m."],"pmcid":["PMC10230622"],"pubmed_authors":["Li Y","Lou S","Gao L","Zou Q","Yang R","Wang W","Zhang L","Shang S"],"additional_accession":[]},"is_claimable":false,"name":"Cytotoxic sesquiterpene aryl esters from <i>Armillaria gallica</i> 012m.","description":"<h4>Objective</h4>To study the chemical constituents of the EtOAc extract of <i>Armillaria gallica</i> 012m.<h4>Methods</h4>The chemical constituents of the EtOAc extract of <i>A. gallica</i> 012m were isolated and purified by various column chromatography and their structures were elucidated on the basis of the 1D and 2D NMR spectroscopic and HRESIMS data. Cytotoxicity of all isolates against A549, HCT-116, M231 and W256 human tumor cells was determined by the MTT method.<h4>Results</h4>A new sesquiterpene aryl ester, armimelleolide C (<b>1</b>), and eight known ones including armillarivin (<b>2</b>), melleolide F (<b>3</b>), 6'-chloromelleolide F (<b>4</b>), melleolide (<b>5</b>), melleolide K (<b>6</b>), melledonol (<b>7</b>), 13-hydroxydihydromelleolide (<b>8</b>), and armillane (<b>9<","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Apr","modification":"2025-04-18T17:46:22.337Z","creation":"2025-04-07T05:21:10.437Z"},"accession":"S-EPMC10230622","cross_references":{"pubmed":["37265767"],"doi":["10.1016/j.chmed.2022.10.003"]}}