{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Morrison MS"],"funding":["BU-CTSI","NCATS NIH HHS","European Union's Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie","NIA NIH HHS","Alzheimer’s Association 2021 Zenith Award","European Union Joint Program for Neurodegenerative Disorders","Swedish government and the County Councils","BrightFocus Foundation","Alzheimer Drug Discovery Foundation","National Institutes of Health","Swedish Research Council","Hjärnfonden, Sweden","Gun and Bertil Stohnes Foundation","Olav Thon Foundation","Anna Lisa and Brother Björnsson’s Foundation","Agneta Prytz-Folkes & Gösta Folkes Foundation","European Research Council","Erling-Persson Family Foundation","NINDS NIH HHS","Alzheimer’s Association Research","Swedish Parkinson Foundation","Gamla Tjänarinnor Foundation","NIA","Aina (Ann) Wallströms and Mary-Ann Sjöbloms Foundation","Swedish Brain Foundation","Swedish Alzheimer Foundation","American Academy of Neurology Career Development Award, Alzheimer’s Association","CSRD VA","NINDS","Swedish Dementia Foundation","International Society for Neurochemistry’s","Stiftelsen för Gamla Tjänarinnor","United States Department of Veterans Affairs","UK Dementia Research Institute at UCL","AD Strategic Fund and the Alzheimer‘s Association","Veterans Affairs Merit Award","Swedish State Support for Clinical Research"],"pagination":["3546-3557"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10233293"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["145(10)"],"pubmed_abstract":["Blood-based biomarkers such as tau phosphorylated at threonine 181 (phosphorylated-tau181) represent an accessible, cost-effective and scalable approach for the in vivo detection of Alzheimer's disease pathophysiology. Plasma-pathological correlation studies are needed to validate plasma phosphorylated-tau181 as an accurate and reliable biomarker of Alzheimer's disease neuropathological changes. This plasma-to-autopsy correlation study included participants from the Boston University Alzheimer's Disease Research Center who had a plasma sample analysed for phosphorylated-tau181 between 2008 and 2018 and donated their brain for neuropathological examination. Plasma phosphorelated-tau181 was measured with single molecule array technology. Of 103 participants, 62 (60.2%) had autopsy-confirmed "],"journal":["Brain : a journal of neurology"],"pubmed_title":["Ante-mortem plasma phosphorylated tau (181) predicts Alzheimer's disease neuropathology and regional tau at autopsy."],"pmcid":["PMC10233293"],"funding_grant_id":["AARGD-20-685362","2018-02532","ADSF-21-831377-C","K23NS102399","FO2019-0228","I01-CX001038","R56 AG062109","AG068753","CX001698","I01 CX001038","850325","K23 NS102399","AF-930627","AG072978","U19 AG068753","L30 NS093634","ADSF-21-831381-C","AG063635","2017-00915","P30AG072978","FO2020-0240","201809-2016862","U54NS115266","860197","IK2 CX002065","ALFGBG-715986","ADSF-21-831376-C","AG062109","JPND2021-00694","I01 CX001698","R01 AG068398","RDAPB-201809-2016615","681712","JPND2019-466-236","U54 NS115266","A2020812F","P30 AG072978","R01AG066524","FO2017-0243","1R01AG068398-01","ZEN-21-848495","UL1 TR001430","R01 NS017950","R44 AG063635","2020-00124","ALFGBG-720931","NS017950","1UL1TR001430","R01 AG066524","AF-742881"],"pubmed_authors":["Morrison MS","Mez J","Goldstein LE","Kowall NW","Budson AE","Zetterberg H","Sugarman MA","McKee AC","Alosco ML","Frank B","Turk KW","Au R","Aparicio HJ","Jun GR","Palmisano JN","Qiu WQ","Stern RA","Martin B","Ashton NJ","Stein TD","Steinberg EG","Tripodis Y","Karikari TK","Blennow K","Killiany R"],"additional_accession":[]},"is_claimable":false,"name":"Ante-mortem plasma phosphorylated tau (181) predicts Alzheimer's disease neuropathology and regional tau at autopsy.","description":"Blood-based biomarkers such as tau phosphorylated at threonine 181 (phosphorylated-tau181) represent an accessible, cost-effective and scalable approach for the in vivo detection of Alzheimer's disease pathophysiology. Plasma-pathological correlation studies are needed to validate plasma phosphorylated-tau181 as an accurate and reliable biomarker of Alzheimer's disease neuropathological changes. This plasma-to-autopsy correlation study included participants from the Boston University Alzheimer's Disease Research Center who had a plasma sample analysed for phosphorylated-tau181 between 2008 and 2018 and donated their brain for neuropathological examination. Plasma phosphorelated-tau181 was measured with single molecule array technology. Of 103 participants, 62 (60.2%) had autopsy-confirmed ","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Oct","modification":"2025-04-19T23:05:59.599Z","creation":"2025-04-19T23:05:59.599Z"},"accession":"S-EPMC10233293","cross_references":{"pubmed":["35554506"],"doi":["10.1093/brain/awac175"]}}