biostudies-literatureMorrison MSBU-CTSINCATS NIH HHSEuropean Union's Horizon 2020 research and innovation programme under the Marie Sklodowska-CurieNIA NIH HHSAlzheimer’s Association 2021 Zenith AwardEuropean Union Joint Program for Neurodegenerative DisordersSwedish government and the County CouncilsBrightFocus FoundationAlzheimer Drug Discovery FoundationNational Institutes of HealthSwedish Research CouncilHjärnfonden, SwedenGun and Bertil Stohnes FoundationOlav Thon FoundationAnna Lisa and Brother Björnsson’s FoundationAgneta Prytz-Folkes & Gösta Folkes FoundationEuropean Research CouncilErling-Persson Family FoundationNINDS NIH HHSAlzheimer’s Association ResearchSwedish Parkinson FoundationGamla Tjänarinnor FoundationNIAAina (Ann) Wallströms and Mary-Ann Sjöbloms FoundationSwedish Brain FoundationSwedish Alzheimer FoundationAmerican Academy of Neurology Career Development Award, Alzheimer’s AssociationCSRD VANINDSSwedish Dementia FoundationInternational Society for Neurochemistry’sStiftelsen för Gamla TjänarinnorUnited States Department of Veterans AffairsUK Dementia Research Institute at UCLAD Strategic Fund and the Alzheimer‘s AssociationVeterans Affairs Merit AwardSwedish State Support for Clinical Research3546-3557https://www.ebi.ac.uk/biostudies/studies/S-EPMC10233293biostudies-literatureUnknown145(10)Blood-based biomarkers such as tau phosphorylated at threonine 181 (phosphorylated-tau181) represent an accessible, cost-effective and scalable approach for the in vivo detection of Alzheimer's disease pathophysiology. Plasma-pathological correlation studies are needed to validate plasma phosphorylated-tau181 as an accurate and reliable biomarker of Alzheimer's disease neuropathological changes. This plasma-to-autopsy correlation study included participants from the Boston University Alzheimer's Disease Research Center who had a plasma sample analysed for phosphorylated-tau181 between 2008 and 2018 and donated their brain for neuropathological examination. Plasma phosphorelated-tau181 was measured with single molecule array technology. Of 103 participants, 62 (60.2%) had autopsy-confirmed Brain : a journal of neurologyAnte-mortem plasma phosphorylated tau (181) predicts Alzheimer's disease neuropathology and regional tau at autopsy.PMC10233293AARGD-20-6853622018-02532ADSF-21-831377-CK23NS102399FO2019-0228I01-CX001038R56 AG062109AG068753CX001698I01 CX001038850325K23 NS102399AF-930627AG072978U19 AG068753L30 NS093634ADSF-21-831381-CAG0636352017-00915P30AG072978FO2020-0240201809-2016862U54NS115266860197IK2 CX002065ALFGBG-715986ADSF-21-831376-CAG062109JPND2021-00694I01 CX001698R01 AG068398RDAPB-201809-2016615681712JPND2019-466-236U54 NS115266A2020812FP30 AG072978R01AG066524FO2017-02431R01AG068398-01ZEN-21-848495UL1 TR001430R01 NS017950R44 AG0636352020-00124ALFGBG-720931NS0179501UL1TR001430R01 AG066524AF-742881Morrison MSMez JGoldstein LEKowall NWBudson AEZetterberg HSugarman MAMcKee ACAlosco MLFrank BTurk KWAu RAparicio HJJun GRPalmisano JNQiu WQStern RAMartin BAshton NJStein TDSteinberg EGTripodis YKarikari TKBlennow KKilliany RfalseAnte-mortem plasma phosphorylated tau (181) predicts Alzheimer's disease neuropathology and regional tau at autopsy.Blood-based biomarkers such as tau phosphorylated at threonine 181 (phosphorylated-tau181) represent an accessible, cost-effective and scalable approach for the in vivo detection of Alzheimer's disease pathophysiology. Plasma-pathological correlation studies are needed to validate plasma phosphorylated-tau181 as an accurate and reliable biomarker of Alzheimer's disease neuropathological changes. This plasma-to-autopsy correlation study included participants from the Boston University Alzheimer's Disease Research Center who had a plasma sample analysed for phosphorylated-tau181 between 2008 and 2018 and donated their brain for neuropathological examination. Plasma phosphorelated-tau181 was measured with single molecule array technology. Of 103 participants, 62 (60.2%) had autopsy-confirmed 2022-01-01T00:00:00Z2022 Oct2025-04-19T23:05:59.599Z2025-04-19T23:05:59.599ZS-EPMC102332933555450610.1093/brain/awac175