{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["14"],"submitter":["Sun L"],"pubmed_abstract":["The emergence and spread of carbapenemase genes, colistin resistance genes <i>mcr-1</i>, and tigecycline resistance gene <i>tet</i>(X) represent a significant threat to clinical therapy and public health. In this study, we investigated the presence of carbapenemase genes, <i>mcr-1</i>, and <i>tet</i>(X) in 298 <i>Escherichia coli</i> strains obtained from a teaching hospital in China. In total, eight (2.68%), six (2.01%), and one (0.34%) <i>E. coli</i> isolates carried <i>bla</i><sub>NDM</sub>, <i>mcr-1</i>, and <i>tet</i>(X4), respectively. The <i>bla</i><sub>NDM</sub> gene was located on IncX3 (<i>n</i> = 4), F2:A-:B- (<i>n</i> = 3), and F2:A1:B1 (<i>n</i> = 1) plasmids, with high similarity to multiple plasmids belonging to the same incompatibility type from Enterobacteriaceae. Six MCR-"],"journal":["Frontiers in microbiology"],"pagination":["1181940"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10237293"],"repository":["biostudies-literature"],"pubmed_title":["Low prevalence of mobilized resistance genes <i>bla</i><sub>NDM</sub>, <i>mcr-1</i>, and <i>tet</i>(X4) in <i>Escherichia coli</i> from a hospital in China."],"pmcid":["PMC10237293"],"pubmed_authors":["Sun L","Jiang Y","Mei CY","Sun GZ","Kong GM","Wang ZY","Wang J","Jiao X","Wang HY"],"additional_accession":[]},"is_claimable":false,"name":"Low prevalence of mobilized resistance genes <i>bla</i><sub>NDM</sub>, <i>mcr-1</i>, and <i>tet</i>(X4) in <i>Escherichia coli</i> from a hospital in China.","description":"The emergence and spread of carbapenemase genes, colistin resistance genes <i>mcr-1</i>, and tigecycline resistance gene <i>tet</i>(X) represent a significant threat to clinical therapy and public health. In this study, we investigated the presence of carbapenemase genes, <i>mcr-1</i>, and <i>tet</i>(X) in 298 <i>Escherichia coli</i> strains obtained from a teaching hospital in China. In total, eight (2.68%), six (2.01%), and one (0.34%) <i>E. coli</i> isolates carried <i>bla</i><sub>NDM</sub>, <i>mcr-1</i>, and <i>tet</i>(X4), respectively. The <i>bla</i><sub>NDM</sub> gene was located on IncX3 (<i>n</i> = 4), F2:A-:B- (<i>n</i> = 3), and F2:A1:B1 (<i>n</i> = 1) plasmids, with high similarity to multiple plasmids belonging to the same incompatibility type from Enterobacteriaceae. Six MCR-","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023","modification":"2026-04-08T15:53:55.369Z","creation":"2024-11-21T05:39:54.539Z"},"accession":"S-EPMC10237293","cross_references":{"pubmed":["37275145"],"doi":["10.3389/fmicb.2023.1181940"]}}