biostudies-literatureUnknown14Sun LThe emergence and spread of carbapenemase genes, colistin resistance genes <i>mcr-1</i>, and tigecycline resistance gene <i>tet</i>(X) represent a significant threat to clinical therapy and public health. In this study, we investigated the presence of carbapenemase genes, <i>mcr-1</i>, and <i>tet</i>(X) in 298 <i>Escherichia coli</i> strains obtained from a teaching hospital in China. In total, eight (2.68%), six (2.01%), and one (0.34%) <i>E. coli</i> isolates carried <i>bla</i>_NDM, <i>mcr-1</i>, and <i>tet</i>(X4), respectively. The <i>bla</i>_NDM gene was located on IncX3 (<i>n</i> = 4), F2:A-:B- (<i>n</i> = 3), and F2:A1:B1 (<i>n</i> = 1) plasmids, with high similarity to multiple plasmids belonging to the same incompatibility type from Enterobacteriaceae. Six MCR-Frontiers in microbiology1181940https://www.ebi.ac.uk/biostudies/studies/S-EPMC10237293biostudies-literatureLow prevalence of mobilized resistance genes <i>bla</i>_NDM, <i>mcr-1</i>, and <i>tet</i>(X4) in <i>Escherichia coli</i> from a hospital in China.PMC10237293Sun LJiang YMei CYSun GZKong GMWang ZYWang JJiao XWang HYfalseLow prevalence of mobilized resistance genes <i>bla</i>_NDM, <i>mcr-1</i>, and <i>tet</i>(X4) in <i>Escherichia coli</i> from a hospital in China.The emergence and spread of carbapenemase genes, colistin resistance genes <i>mcr-1</i>, and tigecycline resistance gene <i>tet</i>(X) represent a significant threat to clinical therapy and public health. In this study, we investigated the presence of carbapenemase genes, <i>mcr-1</i>, and <i>tet</i>(X) in 298 <i>Escherichia coli</i> strains obtained from a teaching hospital in China. In total, eight (2.68%), six (2.01%), and one (0.34%) <i>E. coli</i> isolates carried <i>bla</i>_NDM, <i>mcr-1</i>, and <i>tet</i>(X4), respectively. The <i>bla</i>_NDM gene was located on IncX3 (<i>n</i> = 4), F2:A-:B- (<i>n</i> = 3), and F2:A1:B1 (<i>n</i> = 1) plasmids, with high similarity to multiple plasmids belonging to the same incompatibility type from Enterobacteriaceae. Six MCR-2023-01-01T00:00:00Z20232026-04-08T15:53:55.369Z2024-11-21T05:39:54.539ZS-EPMC102372933727514510.3389/fmicb.2023.1181940