biostudies-literatureUnknown6(6)Wang CJ<h4>Importance</h4>Reperfusion therapy is the most effective treatment for acute ischemic stroke but remains underused in China.<h4>Objective</h4>To evaluate the effect of a problem-oriented, culturally adapted, targeted quality improvement intervention on reperfusion therapy for patients with acute ischemic stroke in China.<h4>Design, setting, and participants</h4>In this stepped-wedge cluster randomized clinical trial, patients from 16 secondary and 33 tertiary hospitals in China with acute ischemic stroke within 6 hours of symptom onset were consecutively recruited between July 1, 2018, and June 30, 2020.<h4>Interventions</h4>Hospitals were randomly assigned to 1 of 3 sequences to receive the targeted quality improvement intervention (n = 5689), in which workflow reconstruction was promJAMA network opene2316465https://www.ebi.ac.uk/biostudies/studies/S-EPMC10238948biostudies-literatureEffectiveness of a Quality Improvement Intervention on Reperfusion Treatment for Patients With Acute Ischemic Stroke: A Stepped-Wedge Cluster Randomized Clinical Trial.PMC10238948Liu LPHuang DLiu XYSchwamm LHGuo ZWang CJZong LXWang HHao YZhang LWang MWang NSun PGuo JLiang HDong JGu JChen SHu SQWang ZLi GLi HYang GYang JJin XLi JChen JChen LXie ZXian YIMPROVE Stroke Care in China investigatorsChen GXu JWang YJYang XWang YLMa XDLi XLi SLi TWangqin RQYang QZhang XMMa QCao MBei YZGu HQRen YLiu PYu JMeng XNiu XZhao XJiang YWang ZMTang MZhao LZhou CLi AZhou QHuo XCZhao XQZhang YHuang XQi XHLi ZXKong XMorgan LMa GfalseEffectiveness of a Quality Improvement Intervention on Reperfusion Treatment for Patients With Acute Ischemic Stroke: A Stepped-Wedge Cluster Randomized Clinical Trial.<h4>Importance</h4>Reperfusion therapy is the most effective treatment for acute ischemic stroke but remains underused in China.<h4>Objective</h4>To evaluate the effect of a problem-oriented, culturally adapted, targeted quality improvement intervention on reperfusion therapy for patients with acute ischemic stroke in China.<h4>Design, setting, and participants</h4>In this stepped-wedge cluster randomized clinical trial, patients from 16 secondary and 33 tertiary hospitals in China with acute ischemic stroke within 6 hours of symptom onset were consecutively recruited between July 1, 2018, and June 30, 2020.<h4>Interventions</h4>Hospitals were randomly assigned to 1 of 3 sequences to receive the targeted quality improvement intervention (n = 5689), in which workflow reconstruction was prom2023-01-01T00:00:00Z2023 Jun2026-05-29T03:24:55.337Z2025-04-06T11:13:29.478ZS-EPMC102389483726694010.1001/jamanetworkopen.2023.16465