biostudies-literatureLiao WScience and Technology Projects of Jiangxi Provincial Education Departmentthe Leading Talents Project of Jiangxi Provincial Science and the Technology Department’s Training Plan for Major Disciplines and Technical Leadersthe Leading Talents Project of Jiangxi Provincial Science and the Technology Department's Training Plan for Major Disciplines and Technical Leadersthe National Natural Science Foundation of ChinaGeneral science and technology projects of Jiangxi Provincial Health Commission300https://www.ebi.ac.uk/biostudies/studies/S-EPMC10239159biostudies-literatureUnknown24(1)<h4>Background</h4>There is a mutual hemodynamic and pathophysiological basis between the heart and brain. Glutamate (GLU) signaling plays an important role in the process of myocardial ischemia (MI) and ischemic stroke (IS). To further explore the common protective mechanism after cardiac and cerebral ischemic injuries, the relationship between GLU receptor-related genes and MI and IS were analyzed.<h4>Results</h4>A total of 25 crosstalk genes were identified, which were mainly enriched in the Toll-like receptor signaling pathway, Th17 cell differentiation, and other signaling pathways. Protein-protein interaction analysis suggested that the top six genes with the most interactions with shared genes were IL6, TLR4, IL1B, SRC, TLR2, and CCL2. Immune infiltration analysis suggested that immBMC genomicsBioinformatics and experimental analyses of glutamate receptor and its targets genes in myocardial and cerebral ischemia.PMC10239159No. 81960326GJ2201436No. 202210884No. 20213BCJ0001Zhou MZeng CHe CHu SLiu ZLuo MLiao WYu JYang SDuan YfalseBioinformatics and experimental analyses of glutamate receptor and its targets genes in myocardial and cerebral ischemia.<h4>Background</h4>There is a mutual hemodynamic and pathophysiological basis between the heart and brain. Glutamate (GLU) signaling plays an important role in the process of myocardial ischemia (MI) and ischemic stroke (IS). To further explore the common protective mechanism after cardiac and cerebral ischemic injuries, the relationship between GLU receptor-related genes and MI and IS were analyzed.<h4>Results</h4>A total of 25 crosstalk genes were identified, which were mainly enriched in the Toll-like receptor signaling pathway, Th17 cell differentiation, and other signaling pathways. Protein-protein interaction analysis suggested that the top six genes with the most interactions with shared genes were IL6, TLR4, IL1B, SRC, TLR2, and CCL2. Immune infiltration analysis suggested that imm2023-01-01T00:00:00Z2023 Jun2026-05-29T19:22:50.139Z2025-04-06T11:13:35.098ZS-EPMC102391593726889410.1186/s12864-023-09408-z