{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Ghufran Rafique M"],"funding":["National Institutes of Health","Canada Foundation for Innovation","NIGMS NIH HHS","National Science Foundation"],"pagination":["e202217814"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10239398"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["62(24)"],"pubmed_abstract":["Two-dimensional (2D) assemblies of water-soluble block copolymers have been limited by a dearth of systematic studies that relate polymer structure to pathway mechanism and supramolecular morphology. Here, we employ sequence-defined triblock DNA amphiphiles for the supramolecular polymerization of free-standing DNA nanosheets in water. Our systematic modulation of amphiphile sequence shows the alkyl chain core forming a cell membrane-like structure and the distal π-stacking chromophore block folding back to interact with the hydrophilic DNA block on the nanosheet surface. This interaction is crucial to sheet formation, marked by a chiral \"signature\", and sensitive to DNA sequence, where nanosheets form with a mixed sequence, but not with a homogeneous poly(thymine) sequence. This work open"],"journal":["Angewandte Chemie (International ed. in English)"],"pubmed_title":["Two-Dimensional Supramolecular Polymerization of DNA Amphiphiles is Driven by Sequence-Dependent DNA-Chromophore Interactions."],"pmcid":["PMC10239398"],"funding_grant_id":["23690","R01GM129431","CHE-1945394","R01 GM129431"],"pubmed_authors":["Perepichka DF","Li J","Remington JM","Ghufran Rafique M","Toader V","Sleiman HF","Bai H","Clark F"],"additional_accession":[]},"is_claimable":false,"name":"Two-Dimensional Supramolecular Polymerization of DNA Amphiphiles is Driven by Sequence-Dependent DNA-Chromophore Interactions.","description":"Two-dimensional (2D) assemblies of water-soluble block copolymers have been limited by a dearth of systematic studies that relate polymer structure to pathway mechanism and supramolecular morphology. Here, we employ sequence-defined triblock DNA amphiphiles for the supramolecular polymerization of free-standing DNA nanosheets in water. Our systematic modulation of amphiphile sequence shows the alkyl chain core forming a cell membrane-like structure and the distal π-stacking chromophore block folding back to interact with the hydrophilic DNA block on the nanosheet surface. This interaction is crucial to sheet formation, marked by a chiral \"signature\", and sensitive to DNA sequence, where nanosheets form with a mixed sequence, but not with a homogeneous poly(thymine) sequence. This work open","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Jun","modification":"2025-07-12T03:04:13.484Z","creation":"2025-07-12T03:04:13.484Z"},"accession":"S-EPMC10239398","cross_references":{"pubmed":["36939824"],"doi":["10.1002/anie.202217814"]}}