{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Shan Z"],"funding":["Natural Science Foundation of Hubei Province","National Natural Science Foundation of China"],"pagination":["65"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10240765"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["24(1)"],"pubmed_abstract":["Migraine is the second highest cause of disability worldwide, bringing a huge socioeconomic burden. Improving mitochondrial function has promise as an effective treatment strategy for migraine. Szeto-Schiller peptide (SS-31) is a new mitochondria-targeted tetrapeptide molecule that has been shown to suppress the progression of diseases by restoring mitochondrial function, including renal disease, cardiac disease, and neurodegenerative disease. However, whether SS-31 has a therapeutic effect on migraine remains unclear. The aim of this study is to clarify the treatment of SS-31 for headache and its potential mechanisms. Here we used a mouse model induced by repeated dural infusion of inflammatory soup (IS), and examined roles of Sirt3/Pgc-1α positive feedback loop in headache pathogenesis a"],"journal":["The journal of headache and pain"],"pubmed_title":["SS-31 alleviated nociceptive responses and restored mitochondrial function in a headache mouse model via Sirt3/Pgc-1α positive feedback loop."],"pmcid":["PMC10240765"],"funding_grant_id":["82101292","2020CFB226","81971055","81801134"],"pubmed_authors":["Shan Z","Zhang Y","Xiao Z","Qiu T","Liang J","Hu L","Zhang L","Wang Y","Zhou Y","Fan S","Ding M"],"additional_accession":[]},"is_claimable":false,"name":"SS-31 alleviated nociceptive responses and restored mitochondrial function in a headache mouse model via Sirt3/Pgc-1α positive feedback loop.","description":"Migraine is the second highest cause of disability worldwide, bringing a huge socioeconomic burden. Improving mitochondrial function has promise as an effective treatment strategy for migraine. Szeto-Schiller peptide (SS-31) is a new mitochondria-targeted tetrapeptide molecule that has been shown to suppress the progression of diseases by restoring mitochondrial function, including renal disease, cardiac disease, and neurodegenerative disease. However, whether SS-31 has a therapeutic effect on migraine remains unclear. The aim of this study is to clarify the treatment of SS-31 for headache and its potential mechanisms. Here we used a mouse model induced by repeated dural infusion of inflammatory soup (IS), and examined roles of Sirt3/Pgc-1α positive feedback loop in headache pathogenesis a","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Jun","modification":"2025-04-04T14:39:36.364Z","creation":"2025-04-04T14:39:36.364Z"},"accession":"S-EPMC10240765","cross_references":{"pubmed":["37271805"],"doi":["10.1186/s10194-023-01600-6"]}}