{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["13(9)"],"submitter":["Wang R"],"pubmed_abstract":["<b>Rationale:</b> Early discovery, accurate diagnosis, and staging of lung cancer is essential for patients to receive appropriate treatment. PET/CT has become increasingly recognized as a valuable imaging modality for these patients, but there remains room for improvement in PET tracers. We aimed to evaluate the feasibility of using [<sup>68</sup>Ga]Ga-FAPI-RGD, a dual-targeting heterodimeric PET tracer that recognizes both fibroblast activation protein (FAP) and integrin α<sub>v</sub>β<sub>3</sub> for detecting lung neoplasms, by comparing it with [<sup>18</sup>F]FDG and single-targeting tracers [<sup>68</sup>Ga]Ga-RGD and [<sup>68</sup>Ga]Ga-FAPI. <b>Methods:</b> This was a pilot exploratory study of patients with suspected lung malignancies. All 51 participants underwent [<sup>68</sup>"],"journal":["Theranostics"],"pagination":["2979-2992"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10240811"],"repository":["biostudies-literature"],"pubmed_title":["Dual targeting PET tracer [<sup>68</sup>Ga]Ga-FAPI-RGD in patients with lung neoplasms: a pilot exploratory study."],"pmcid":["PMC10240811"],"pubmed_authors":["Peng X","Zhu Z","Wang R","Zhang J","Jakobsson V","Zhao T","Li B","Liang N","Chen X","Xue J","Wang J"],"additional_accession":[]},"is_claimable":false,"name":"Dual targeting PET tracer [<sup>68</sup>Ga]Ga-FAPI-RGD in patients with lung neoplasms: a pilot exploratory study.","description":"<b>Rationale:</b> Early discovery, accurate diagnosis, and staging of lung cancer is essential for patients to receive appropriate treatment. PET/CT has become increasingly recognized as a valuable imaging modality for these patients, but there remains room for improvement in PET tracers. We aimed to evaluate the feasibility of using [<sup>68</sup>Ga]Ga-FAPI-RGD, a dual-targeting heterodimeric PET tracer that recognizes both fibroblast activation protein (FAP) and integrin α<sub>v</sub>β<sub>3</sub> for detecting lung neoplasms, by comparing it with [<sup>18</sup>F]FDG and single-targeting tracers [<sup>68</sup>Ga]Ga-RGD and [<sup>68</sup>Ga]Ga-FAPI. <b>Methods:</b> This was a pilot exploratory study of patients with suspected lung malignancies. All 51 participants underwent [<sup>68</sup>","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023","modification":"2026-07-14T21:11:19.116Z","creation":"2025-04-06T14:08:39.702Z"},"accession":"S-EPMC10240811","cross_references":{"pubmed":["37284441"],"doi":["10.7150/thno.86007"]}}