biostudies-literatureUnknown13(9)Wang R<b>Rationale:</b> Early discovery, accurate diagnosis, and staging of lung cancer is essential for patients to receive appropriate treatment. PET/CT has become increasingly recognized as a valuable imaging modality for these patients, but there remains room for improvement in PET tracers. We aimed to evaluate the feasibility of using [⁶⁸Ga]Ga-FAPI-RGD, a dual-targeting heterodimeric PET tracer that recognizes both fibroblast activation protein (FAP) and integrin α_vβ₃ for detecting lung neoplasms, by comparing it with [¹⁸F]FDG and single-targeting tracers [⁶⁸Ga]Ga-RGD and [⁶⁸Ga]Ga-FAPI. <b>Methods:</b> This was a pilot exploratory study of patients with suspected lung malignancies. All 51 participants underwent [⁶⁸Theranostics2979-2992https://www.ebi.ac.uk/biostudies/studies/S-EPMC10240811biostudies-literatureDual targeting PET tracer [⁶⁸Ga]Ga-FAPI-RGD in patients with lung neoplasms: a pilot exploratory study.PMC10240811Peng XZhu ZWang RZhang JJakobsson VZhao TLi BLiang NChen XXue JWang JfalseDual targeting PET tracer [⁶⁸Ga]Ga-FAPI-RGD in patients with lung neoplasms: a pilot exploratory study.<b>Rationale:</b> Early discovery, accurate diagnosis, and staging of lung cancer is essential for patients to receive appropriate treatment. PET/CT has become increasingly recognized as a valuable imaging modality for these patients, but there remains room for improvement in PET tracers. We aimed to evaluate the feasibility of using [⁶⁸Ga]Ga-FAPI-RGD, a dual-targeting heterodimeric PET tracer that recognizes both fibroblast activation protein (FAP) and integrin α_vβ₃ for detecting lung neoplasms, by comparing it with [¹⁸F]FDG and single-targeting tracers [⁶⁸Ga]Ga-RGD and [⁶⁸Ga]Ga-FAPI. <b>Methods:</b> This was a pilot exploratory study of patients with suspected lung malignancies. All 51 participants underwent [⁶⁸2023-01-01T00:00:00Z20232026-07-14T21:11:19.116Z2025-04-06T14:08:39.702ZS-EPMC102408113728444110.7150/thno.86007