{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["13(9)"],"submitter":["Tan D"],"pubmed_abstract":["<b>Background:</b> Safe and effective wound healing can be a major clinical challenge. Inflammation and vascular impairment are two main causes of inadequate wound healing. <b>Methods:</b> Here, we developed a versatile hydrogel wound dressing, comprising a straightforward physical mixture of royal jelly-derived extracellular vesicles (RJ-EVs) and methacrylic anhydride modified sericin (SerMA), to accelerate wound healing by inhibiting inflammation and promoting vascular reparation. <b>Results:</b> The RJ-EVs showed satisfactory anti-inflammatory and antioxidant effects, and significantly promoted L929 cell proliferation and migration <i>in vitro</i>. Meanwhile, the photocrosslinked SerMA hydrogel with its porous interior structure and high fluidity made it a good candidate for wound dressing. The RJ-EVs can be gradually released from the SerMA hydrogel at the wound site, ensuring the restorative effect of RJ-EVs. In a full-thickness skin defect model, the SerMA/RJ-EVs hydrogel dressing accelerated wound healing with a healing rate of 96.8% by improving cell proliferation and angiogenesis. The RNA sequencing results further revealed that the SerMA/RJ-EVs hydrogel dressing was involved in inflammatory damage repair-related pathways including recombinational repair, epidermis development, and Wnt signaling. <b>Conclusion:</b> This SerMA/RJ-EVs hydrogel dressing offers a simple, safe and robust strategy for modulating inflammation and vascular impairment for accelerated wound healing."],"journal":["Theranostics"],"pagination":["2811-2824"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10240823"],"repository":["biostudies-literature"],"pubmed_title":["<i>In situ</i> formed scaffold with royal jelly-derived extracellular vesicles for wound healing."],"pmcid":["PMC10240823"],"pubmed_authors":["Pan Y","Liu L","Tan D","Zhu W","Huang Q","Li L","Rao L","Xu Y"],"additional_accession":[]},"is_claimable":false,"name":"<i>In situ</i> formed scaffold with royal jelly-derived extracellular vesicles for wound healing.","description":"<b>Background:</b> Safe and effective wound healing can be a major clinical challenge. Inflammation and vascular impairment are two main causes of inadequate wound healing. <b>Methods:</b> Here, we developed a versatile hydrogel wound dressing, comprising a straightforward physical mixture of royal jelly-derived extracellular vesicles (RJ-EVs) and methacrylic anhydride modified sericin (SerMA), to accelerate wound healing by inhibiting inflammation and promoting vascular reparation. <b>Results:</b> The RJ-EVs showed satisfactory anti-inflammatory and antioxidant effects, and significantly promoted L929 cell proliferation and migration <i>in vitro</i>. Meanwhile, the photocrosslinked SerMA hydrogel with its porous interior structure and high fluidity made it a good candidate for wound dressing. The RJ-EVs can be gradually released from the SerMA hydrogel at the wound site, ensuring the restorative effect of RJ-EVs. In a full-thickness skin defect model, the SerMA/RJ-EVs hydrogel dressing accelerated wound healing with a healing rate of 96.8% by improving cell proliferation and angiogenesis. The RNA sequencing results further revealed that the SerMA/RJ-EVs hydrogel dressing was involved in inflammatory damage repair-related pathways including recombinational repair, epidermis development, and Wnt signaling. <b>Conclusion:</b> This SerMA/RJ-EVs hydrogel dressing offers a simple, safe and robust strategy for modulating inflammation and vascular impairment for accelerated wound healing.","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023","modification":"2025-04-04T07:59:30.287Z","creation":"2025-04-04T07:59:30.287Z"},"accession":"S-EPMC10240823","cross_references":{"pubmed":["37284440"],"doi":["10.7150/thno.84665"]}}