{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["13(9)"],"submitter":["Fu Y"],"pubmed_abstract":["<b>Rationale:</b> Cisplatin, a potent chemotherapeutic drug, induces side effects in normal tissues including the kidney. To reduce the side effects, repeated low-dose cisplatin (RLDC) is commonly used in clinical setting. While RLDC reduces acute nephrotoxicity to certain extents, a significant portion of patients later develop chronic kidney problems, underscoring the need for novel therapeutics to alleviate the long-term sequelae of RLDC therapy. <b>Methods:</b> <i>In vivo</i>, the role of HMGB1 was examined by testing HMGB1 neutralizing antibodies in RLDC mice. <i>In vitro</i>, the effects of HMGB1 knockdown on RLDC-induced nuclear factor-κB (NF-κB) activation and fibrotic phenotype changes were tested in proximal tubular cells. To study signal transducer and activator of transcription"],"journal":["Theranostics"],"pagination":["2757-2773"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10240827"],"repository":["biostudies-literature"],"pubmed_title":["The STAT1/HMGB1/NF-κB pathway in chronic inflammation and kidney injury after cisplatin exposure."],"pmcid":["PMC10240827"],"pubmed_authors":["Liu Z","Dong Z","Tang C","Cai J","Chen G","Fu Y","Xiang Y","Zha J","Wang Y","Yang D"],"additional_accession":[]},"is_claimable":false,"name":"The STAT1/HMGB1/NF-κB pathway in chronic inflammation and kidney injury after cisplatin exposure.","description":"<b>Rationale:</b> Cisplatin, a potent chemotherapeutic drug, induces side effects in normal tissues including the kidney. To reduce the side effects, repeated low-dose cisplatin (RLDC) is commonly used in clinical setting. While RLDC reduces acute nephrotoxicity to certain extents, a significant portion of patients later develop chronic kidney problems, underscoring the need for novel therapeutics to alleviate the long-term sequelae of RLDC therapy. <b>Methods:</b> <i>In vivo</i>, the role of HMGB1 was examined by testing HMGB1 neutralizing antibodies in RLDC mice. <i>In vitro</i>, the effects of HMGB1 knockdown on RLDC-induced nuclear factor-κB (NF-κB) activation and fibrotic phenotype changes were tested in proximal tubular cells. To study signal transducer and activator of transcription","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023","modification":"2026-05-29T03:28:01.781Z","creation":"2025-04-06T11:13:49.751Z"},"accession":"S-EPMC10240827","cross_references":{"pubmed":["37284446"],"doi":["10.7150/thno.81406"]}}