{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["2"],"submitter":["Kasper BS"],"pubmed_abstract":["50 years ago back in 1971, David C. Taylor and colleagues from England reported on a small series of surgical epilepsy cases proposing a new type of tissue lesion as a cause of difficult-to-treat focal epilepsy: a localized malformation of cerebral cortex. The lesion is now known as focal cortical dysplasia (FCD) Type II or Taylor's cortical dysplasia. FCD II is not rare, and today is a frequent finding in neurosurgical epilepsy specimens. Medical progress has been achieved in that the majority of FCD II is diagnosed non-invasively by magnetic resonance imaging today. Detailed studies on FCD revealed that the lesion belongs to a spectrum of mTOR-o-pathies, thereby confirming the authors´ initial hypothesis of a relationship to tuberous sclerosis. Here, selected original materials from Tayl"],"journal":["Free neuropathology"],"pagination":["11"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10240934"],"repository":["biostudies-literature"],"pubmed_title":["Taylor's focal cortical dysplasia revisited: History, original specimens and impact."],"pmcid":["PMC10240934"],"pubmed_authors":["Kasper BS"],"additional_accession":[]},"is_claimable":false,"name":"Taylor's focal cortical dysplasia revisited: History, original specimens and impact.","description":"50 years ago back in 1971, David C. Taylor and colleagues from England reported on a small series of surgical epilepsy cases proposing a new type of tissue lesion as a cause of difficult-to-treat focal epilepsy: a localized malformation of cerebral cortex. The lesion is now known as focal cortical dysplasia (FCD) Type II or Taylor's cortical dysplasia. FCD II is not rare, and today is a frequent finding in neurosurgical epilepsy specimens. Medical progress has been achieved in that the majority of FCD II is diagnosed non-invasively by magnetic resonance imaging today. Detailed studies on FCD revealed that the lesion belongs to a spectrum of mTOR-o-pathies, thereby confirming the authors´ initial hypothesis of a relationship to tuberous sclerosis. Here, selected original materials from Tayl","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Jan","modification":"2026-06-06T22:11:57.208Z","creation":"2025-04-19T17:50:45.139Z"},"accession":"S-EPMC10240934","cross_references":{"pubmed":["37284620"],"doi":["10.17879/freeneuropathology-2021-3324"]}}