{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Sack DE"],"funding":["NCATS","NCATS NIH HHS","NIAID NIH HHS","NIMH NIH HHS","National Institute of Mental Health","National Institutes of Health","NIAID","NIGMS NIH HHS","NIGMS"],"pagination":["1732-1740"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10241982"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["35(11)"],"pubmed_abstract":["Approximately 15% of people with HIV in sub-Saharan Africa have comorbid depression, which impacts treatment outcomes. We describe predictors of baseline depressive symptoms in 1079 female and 1079 male participants in a cluster-randomized trial in Zambézia Province, Mozambique from November 2017 to December 2020. We modeled each partners' depressive symptoms (Patient Health Questionnaire-9 [PHQ-9]) using proportional odds models adjusted for enrollment date, age, body mass index [BMI], partner's PHQ-9 score, district, relationship status, education, occupation, WHO HIV clinical stage, and antiretroviral therapy use history. A <i>post hoc</i> analysis assessed covariate-adjusted rank correlation between partner depressive symptoms. Females were younger than males (median 23 vs. 28 years) and more likely to report no education (20.7% vs. 7.9%). Approximately 10% screened positive for depression (PHQ-9 score ≥ 10). Partner depressive symptoms were predictive of higher participant PHQ-9 scores. A male partner PHQ-9 score of 10 (versus 5) increased the odds that the female partner would have a higher PHQ-9 score (adjusted odds ratio: 7.25, 95% Confidence Interval [CI]: 5.43-9.67). Partner PHQ-9 scores were highly correlated after covariate adjustment (Spearman's rho 0.65, 95% CI 0.57-0.72). Interventions aimed to reduce depressive symptoms and improve HIV-related outcomes during pregnancy should address both partners' depressive symptoms."],"journal":["AIDS care"],"pubmed_title":["Correlated depressive symptoms within seroconcordant, expectant partners living with HIV in Zambezia Province, Mozambique: a cross-sectional study."],"pmcid":["PMC10241982"],"funding_grant_id":["T32 GM152284","R01 MH113478","R01 AI093234","F30 MH123219","T32 GM007347","UL1 TR000445"],"pubmed_authors":["Shepherd BE","Sack DE","De Schacht C","Audet CM","Emilio A","Graves E","Matino A"],"additional_accession":[]},"is_claimable":false,"name":"Correlated depressive symptoms within seroconcordant, expectant partners living with HIV in Zambezia Province, Mozambique: a cross-sectional study.","description":"Approximately 15% of people with HIV in sub-Saharan Africa have comorbid depression, which impacts treatment outcomes. We describe predictors of baseline depressive symptoms in 1079 female and 1079 male participants in a cluster-randomized trial in Zambézia Province, Mozambique from November 2017 to December 2020. We modeled each partners' depressive symptoms (Patient Health Questionnaire-9 [PHQ-9]) using proportional odds models adjusted for enrollment date, age, body mass index [BMI], partner's PHQ-9 score, district, relationship status, education, occupation, WHO HIV clinical stage, and antiretroviral therapy use history. A <i>post hoc</i> analysis assessed covariate-adjusted rank correlation between partner depressive symptoms. Females were younger than males (median 23 vs. 28 years) and more likely to report no education (20.7% vs. 7.9%). Approximately 10% screened positive for depression (PHQ-9 score ≥ 10). Partner depressive symptoms were predictive of higher participant PHQ-9 scores. A male partner PHQ-9 score of 10 (versus 5) increased the odds that the female partner would have a higher PHQ-9 score (adjusted odds ratio: 7.25, 95% Confidence Interval [CI]: 5.43-9.67). Partner PHQ-9 scores were highly correlated after covariate adjustment (Spearman's rho 0.65, 95% CI 0.57-0.72). Interventions aimed to reduce depressive symptoms and improve HIV-related outcomes during pregnancy should address both partners' depressive symptoms.","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Nov","modification":"2025-04-04T03:01:13.879Z","creation":"2025-04-04T03:01:13.879Z"},"accession":"S-EPMC10241982","cross_references":{"pubmed":["36473205"],"doi":["10.1080/09540121.2022.2151558"]}}