{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Kongsomboonvech AK"],"funding":["Hellman Foundation","NIAID NIH HHS","National Institutes of Health"],"pagination":["1130965"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10242045"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["13"],"pubmed_abstract":["<h4>Introduction</h4><i>Toxoplasma gondii</i> induces a strong CD8 T cell response characterized by the secretion of IFNγ that promotes host survival during infection. The initiation of CD8 T cell IFNγ responses <i>in vitro</i> differs widely between clonal lineage strains of <i>T. gondii</i>, in which type I strains are low inducers, while types II and III strains are high inducers. We hypothesized this phenotype is due to a polymorphic \"Regulator Of CD8 T cell Response\" (ROCTR).<h4>Methods</h4>Therefore, we screened F1 progeny from genetic crosses between the clonal lineage strains to identify ROCTR. Naïve antigen-specific CD8 T cells (T57) isolated from transnuclear mice, which are specific for the endogenous and vacuolar TGD057 antigen, were measured for their ability to become activat"],"journal":["Frontiers in cellular and infection microbiology"],"pubmed_title":["Variation in CD8 T cell IFNγ differentiation to strains of <i>Toxoplasma gondii</i> is characterized by small effect QTLs with contribution from ROP16."],"pmcid":["PMC10242045"],"funding_grant_id":["R01 AI137126","R15 AI131027"],"pubmed_authors":["Garcia-Lopez L","Rosenberg A","Rodriguez F","Njume F","Jensen KDC","Kongsomboonvech AK","Souza SP"],"additional_accession":[]},"is_claimable":false,"name":"Variation in CD8 T cell IFNγ differentiation to strains of <i>Toxoplasma gondii</i> is characterized by small effect QTLs with contribution from ROP16.","description":"<h4>Introduction</h4><i>Toxoplasma gondii</i> induces a strong CD8 T cell response characterized by the secretion of IFNγ that promotes host survival during infection. The initiation of CD8 T cell IFNγ responses <i>in vitro</i> differs widely between clonal lineage strains of <i>T. gondii</i>, in which type I strains are low inducers, while types II and III strains are high inducers. We hypothesized this phenotype is due to a polymorphic \"Regulator Of CD8 T cell Response\" (ROCTR).<h4>Methods</h4>Therefore, we screened F1 progeny from genetic crosses between the clonal lineage strains to identify ROCTR. Naïve antigen-specific CD8 T cells (T57) isolated from transnuclear mice, which are specific for the endogenous and vacuolar TGD057 antigen, were measured for their ability to become activat","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023","modification":"2026-04-08T13:13:58.153Z","creation":"2024-11-21T09:32:57.507Z"},"accession":"S-EPMC10242045","cross_references":{"pubmed":["37287466"],"doi":["10.3389/fcimb.2023.1130965"]}}