{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Tran TDB"],"funding":["NIDA NIH HHS","National Institute on Drug Abuse"],"pagination":["e12845"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10242200"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["22(3)"],"pubmed_abstract":["The gut-brain axis is increasingly recognized as an important pathway involved in cocaine use disorder. Microbial products of the murine gut have been shown to affect striatal gene expression, and depletion of the microbiome by antibiotic treatment alters cocaine-induced behavioral sensitization in C57BL/6J male mice. Some reports suggest that cocaine-induced behavioral sensitization is correlated with drug self-administration behavior in mice. Here, we profile the composition of the naïve microbiome and its response to cocaine sensitization in two collaborative cross (CC) strains. These strains display extremely divergent behavioral responses to cocaine sensitization. A high-responding strain, CC004/TauUncJ (CC04), has a gut microbiome that contains a greater amount of Lactobacillus than "],"journal":["Genes, brain, and behavior"],"pubmed_title":["The microbial community dynamics of cocaine sensitization in two behaviorally divergent strains of collaborative cross mice."],"pmcid":["PMC10242200"],"funding_grant_id":["U01DA043809","U01 DA043809","P50 DA039841","P50DA039841"],"pubmed_authors":["Tran TDB","Bubier JA","Nguyen H","Center for Systems Neurogenetics of Addiction","Monroy Hernandez C","Chesler EJ","Weinstock GM","Zhou Y","Wright S","Tarantino LM"],"additional_accession":[]},"is_claimable":false,"name":"The microbial community dynamics of cocaine sensitization in two behaviorally divergent strains of collaborative cross mice.","description":"The gut-brain axis is increasingly recognized as an important pathway involved in cocaine use disorder. Microbial products of the murine gut have been shown to affect striatal gene expression, and depletion of the microbiome by antibiotic treatment alters cocaine-induced behavioral sensitization in C57BL/6J male mice. Some reports suggest that cocaine-induced behavioral sensitization is correlated with drug self-administration behavior in mice. Here, we profile the composition of the naïve microbiome and its response to cocaine sensitization in two collaborative cross (CC) strains. These strains display extremely divergent behavioral responses to cocaine sensitization. A high-responding strain, CC004/TauUncJ (CC04), has a gut microbiome that contains a greater amount of Lactobacillus than ","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Jun","modification":"2026-05-28T19:56:39.709Z","creation":"2025-04-19T07:23:52.623Z"},"accession":"S-EPMC10242200","cross_references":{"pubmed":["37114320"],"doi":["10.1111/gbb.12845"]}}