biostudies-literatureSiegel SDNational Institute of General Medical SciencesNIGMS NIH HHS11760-11772https://www.ebi.ac.uk/biostudies/studies/S-EPMC10242317biostudies-literatureUnknown12(10)<h4>Background</h4>Despite similar incidence rates among Black and White women, breast cancer mortality rates are 40% higher among Black women. More than half of the racial difference in breast cancer mortality can be attributed to triple negative breast cancer (TNBC), an aggressive subtype of invasive breast cancer that disproportionately affects Black women. Recent research has implicated neighborhood conditions in the etiology of TNBC. This study investigated the relationship between cumulative neighborhood-level exposures and TNBC risk.<h4>Methods</h4>This single-institution retrospective study was conducted on a cohort of 3316 breast cancer cases from New Castle County, Delaware (from 2012 to 2020), an area of the country with elevated TNBC rates. Cases were stratified into TNBC and "Cancer medicineNeighborhood factors and triple negative breast cancer: The role of cumulative exposure to area-level risk factors.PMC10242317P20 GM103446Schug ZTBerman JDSims-Mourtada JSiegel SDLynch SMBrooks MMCurriero FCfalseNeighborhood factors and triple negative breast cancer: The role of cumulative exposure to area-level risk factors.<h4>Background</h4>Despite similar incidence rates among Black and White women, breast cancer mortality rates are 40% higher among Black women. More than half of the racial difference in breast cancer mortality can be attributed to triple negative breast cancer (TNBC), an aggressive subtype of invasive breast cancer that disproportionately affects Black women. Recent research has implicated neighborhood conditions in the etiology of TNBC. This study investigated the relationship between cumulative neighborhood-level exposures and TNBC risk.<h4>Methods</h4>This single-institution retrospective study was conducted on a cohort of 3316 breast cancer cases from New Castle County, Delaware (from 2012 to 2020), an area of the country with elevated TNBC rates. Cases were stratified into TNBC and "2023-01-01T00:00:00Z2023 May2025-04-04T14:39:13.192Z2025-04-04T14:39:13.192ZS-EPMC102423173691668710.1002/cam4.5808