{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["54(1)"],"submitter":["Rutjens S"],"pubmed_abstract":["Cephalosporins are licensed for treatment of severe bacterial infections in different species. However, the effect of these antimicrobials on the fecal microbiome and potential spread of resistance-associated genes causes great concern. This highlights the need to understand the impact of cephalosporins on the porcine fecal microbiome and resistome. A combination of long-read 16S rRNA gene and shotgun metagenomic sequencing was applied to investigate the effect of conventional treatment with either ceftiofur (3 mg.kg<sup>-1</sup> intramuscular, 3 consecutive days) or cefquinome (2 mg.kg<sup>-1</sup> intramuscular, 5 consecutive days) on the porcine microbiome and resistome. Fecal samples were collected from 17 pigs (6 ceftiofur treated, 6 cefquinome treated, 5 control pigs) at four differe"],"journal":["Veterinary research"],"pagination":["45"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10242799"],"repository":["biostudies-literature"],"pubmed_title":["Cefquinome shows a higher impact on the pig gut microbiome and resistome compared to ceftiofur."],"pmcid":["PMC10242799"],"pubmed_authors":["Sauer J","Rutjens S","Croubels S","Vereecke N","Devreese M"],"additional_accession":[]},"is_claimable":false,"name":"Cefquinome shows a higher impact on the pig gut microbiome and resistome compared to ceftiofur.","description":"Cephalosporins are licensed for treatment of severe bacterial infections in different species. However, the effect of these antimicrobials on the fecal microbiome and potential spread of resistance-associated genes causes great concern. This highlights the need to understand the impact of cephalosporins on the porcine fecal microbiome and resistome. A combination of long-read 16S rRNA gene and shotgun metagenomic sequencing was applied to investigate the effect of conventional treatment with either ceftiofur (3 mg.kg<sup>-1</sup> intramuscular, 3 consecutive days) or cefquinome (2 mg.kg<sup>-1</sup> intramuscular, 5 consecutive days) on the porcine microbiome and resistome. Fecal samples were collected from 17 pigs (6 ceftiofur treated, 6 cefquinome treated, 5 control pigs) at four differe","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Jun","modification":"2026-05-29T06:35:31.631Z","creation":"2025-04-22T14:01:06.26Z"},"accession":"S-EPMC10242799","cross_references":{"pubmed":["37280708"],"doi":["10.1186/s13567-023-01176-8"]}}