{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zhang Y"],"funding":["Dutch Research Council (NWO)"],"pagination":["e12114"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10242825"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["2(4)"],"pubmed_abstract":["<h4>Background</h4>Childhood internalizing and externalizing problems frequently co-occur. Many studies report neural correlates of either internalizing or externalizing problems, but few account for their co-occurrence. We aimed to assess specific cortical substrates of these psychiatric problems.<h4>Methods</h4>We used data from 9635 children aged 9-11 years in the baseline Adolescent Brain Cognitive Development Study. Internalizing and externalizing problem composite scales scores were derived from the Child Behavior Checklist. We standardized FreeSurfer-derived volumes of 68 cortical regions. We examined internalizing and externalizing problems separately and jointly (covariate-adjustment) in relation to cortical volumes, with and without adjusting for total brain volume (TBV) in multi"],"journal":["JCPP advances"],"pubmed_title":["Differences in cortical morphology and child internalizing or externalizing problems: Accounting for the co-occurrence."],"pmcid":["PMC10242825"],"funding_grant_id":["016.VICI.170.200"],"pubmed_authors":["Muetzel R","Delaney SW","Kim HH","Zhang Y","Xu B","Tiemeier H"],"additional_accession":[]},"is_claimable":false,"name":"Differences in cortical morphology and child internalizing or externalizing problems: Accounting for the co-occurrence.","description":"<h4>Background</h4>Childhood internalizing and externalizing problems frequently co-occur. Many studies report neural correlates of either internalizing or externalizing problems, but few account for their co-occurrence. We aimed to assess specific cortical substrates of these psychiatric problems.<h4>Methods</h4>We used data from 9635 children aged 9-11 years in the baseline Adolescent Brain Cognitive Development Study. Internalizing and externalizing problem composite scales scores were derived from the Child Behavior Checklist. We standardized FreeSurfer-derived volumes of 68 cortical regions. We examined internalizing and externalizing problems separately and jointly (covariate-adjustment) in relation to cortical volumes, with and without adjusting for total brain volume (TBV) in multi","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Dec","modification":"2025-04-22T02:52:13.425Z","creation":"2025-04-05T20:31:03.155Z"},"accession":"S-EPMC10242825","cross_references":{"pubmed":["37431413"],"doi":["10.1002/jcv2.12114"]}}