biostudies-literatureXu HNatural Science Foundation of Gansu ProvinceSpecial Fund for Doctoral Student Training of Lanzhou University Second HospitalKey Talent Project of Gansu ProvinceSpecial Scientific Research Fund for Talent Introduction of Lanzhou University Second Hospital123https://www.ebi.ac.uk/biostudies/studies/S-EPMC10242987biostudies-literatureUnknown16(1)<h4>Background</h4>Glycosylation involved in various biological function, aberrant glycosylation plays an important role in cancer development and progression. Glycosyltransferase 8 domain containing 1 (GLT8D1) and GLT8D2, as members of the glycosyltransferase family proteins, are associated with transferase activity. However, the association between GLT8D1/2 and gastric cancer (GC) remains unclear. We aimed to investigate the potential prognostic value and oncogenic role of GLT8D1/2 in GC.<h4>Methods</h4>The relationship between GLT8D1/2 and GC was evaluated through comprehensive bioinformatics approaches. A series of factors like gene expression patterns, Kaplan-Meier survival analyses, Cox regression analyses, prognostic nomogram, calibration curves, ROC curves, function enrichment analBMC medical genomicsGlycosyltransferase GLT8D1 and GLT8D2 serve as potential prognostic biomarkers correlated with Tumor Immunity in Gastric Cancer.PMC10242987YJS-BD-2622JR5RA9602022RCXM0712015-2-01Zhang DMa XHuang KLin YXu HGong HfalseGlycosyltransferase GLT8D1 and GLT8D2 serve as potential prognostic biomarkers correlated with Tumor Immunity in Gastric Cancer.<h4>Background</h4>Glycosylation involved in various biological function, aberrant glycosylation plays an important role in cancer development and progression. Glycosyltransferase 8 domain containing 1 (GLT8D1) and GLT8D2, as members of the glycosyltransferase family proteins, are associated with transferase activity. However, the association between GLT8D1/2 and gastric cancer (GC) remains unclear. We aimed to investigate the potential prognostic value and oncogenic role of GLT8D1/2 in GC.<h4>Methods</h4>The relationship between GLT8D1/2 and GC was evaluated through comprehensive bioinformatics approaches. A series of factors like gene expression patterns, Kaplan-Meier survival analyses, Cox regression analyses, prognostic nomogram, calibration curves, ROC curves, function enrichment anal2023-01-01T00:00:00Z2023 Jun2025-04-04T14:39:05.369Z2025-02-19T03:55:18.77ZS-EPMC102429873727785310.1186/s12920-023-01559-y