{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Ma J"],"funding":["National Natural Science Foundation Project","Natural Science Foundation Project of Chongqing","Joint Medical Research Project of Chongqing Health Commission and Science and Technology Bureau"],"pagination":["252"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10243060"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["23(1)"],"pubmed_abstract":["<h4>Background</h4>Primary Sjögren's syndrome (pSS) is a chronic autoimmune disorder defined by xerostomia and keratoconjunctivitis sicca, and its etiology remains unknown. N6-methyladenosine (m<sup>6</sup>A) is the predominant posttranscriptional modification in eukaryotic mRNAs and is dynamically regulated by m<sup>6</sup>A regulators. Dysregulation of m<sup>6</sup>A modification is closely associated with several autoimmune disorders, but the role of m<sup>6</sup>A modification in pSS remains unknown. This study investigated the potential role of m<sup>6</sup>A and m<sup>6</sup>A-related regulators in pSS patients with dry eye.<h4>Methods</h4>This cross-sectional study included forty-eight pSS patients with dry eye and forty healthy controls (HCs). Peripheral blood mononuclear cells (PB"],"journal":["BMC ophthalmology"],"pubmed_title":["Increased METTL3 expression and m<sup>6</sup>A RNA methylation may contribute to the development of dry eye in primary Sjogren's syndrome."],"pmcid":["PMC10243060"],"funding_grant_id":["82070935","2019MSXM003","cstc2019jcyj-msxmX0398"],"pubmed_authors":["Yang X","Fang H","Tan T","Ma J","Wang X","Zhong Y","Zhang Q"],"additional_accession":[]},"is_claimable":false,"name":"Increased METTL3 expression and m<sup>6</sup>A RNA methylation may contribute to the development of dry eye in primary Sjogren's syndrome.","description":"<h4>Background</h4>Primary Sjögren's syndrome (pSS) is a chronic autoimmune disorder defined by xerostomia and keratoconjunctivitis sicca, and its etiology remains unknown. N6-methyladenosine (m<sup>6</sup>A) is the predominant posttranscriptional modification in eukaryotic mRNAs and is dynamically regulated by m<sup>6</sup>A regulators. Dysregulation of m<sup>6</sup>A modification is closely associated with several autoimmune disorders, but the role of m<sup>6</sup>A modification in pSS remains unknown. This study investigated the potential role of m<sup>6</sup>A and m<sup>6</sup>A-related regulators in pSS patients with dry eye.<h4>Methods</h4>This cross-sectional study included forty-eight pSS patients with dry eye and forty healthy controls (HCs). Peripheral blood mononuclear cells (PB","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Jun","modification":"2025-04-19T14:13:47.55Z","creation":"2024-11-07T00:54:35.537Z"},"accession":"S-EPMC10243060","cross_references":{"pubmed":["37277716"],"doi":["10.1186/s12886-023-02988-0"]}}