{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Kotas ME"],"funding":["NIAID NIH HHS","NHLBI NIH HHS"],"pagination":["1277-1285"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10243183"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["151(5)"],"pubmed_abstract":["<h4>Background</h4>Epithelial remodeling is a histopathologic feature of chronic inflammatory airway diseases including chronic rhinosinusitis (CRS). Cell-type shifts and their relationship to CRS endotypes and severity are incompletely described.<h4>Objective</h4>We sought to understand the relationship of epithelial cell remodeling to inflammatory endotypes and disease outcomes in CRS.<h4>Methods</h4>Using cell-type transcriptional signatures derived from epithelial single-cell sequencing, we analyzed bulk RNA-sequencing data from sinus epithelial brushings obtained from patients with CRS with and without nasal polyps in comparison to healthy controls.<h4>Results</h4>The airway epithelium in nasal polyposis displayed increased tuft cell transcripts and decreased ciliated cell transcripts"],"journal":["The Journal of allergy and clinical immunology"],"pubmed_title":["IL-13-associated epithelial remodeling correlates with clinical severity in nasal polyposis."],"pmcid":["PMC10243183"],"funding_grant_id":["F32 HL158174","P01 HL107202","R15 AI147148","R01 HL135156","P01 HL132821","F32 HL140868","R01 AI136962","T32 HL007185","R01 HL128439"],"pubmed_authors":["Gordon ED","Cope EK","Pletcher SD","Moore CM","Patel NN","Gurrola JG","Goldberg AN","Kotas ME","Seibold MA"],"additional_accession":[]},"is_claimable":false,"name":"IL-13-associated epithelial remodeling correlates with clinical severity in nasal polyposis.","description":"<h4>Background</h4>Epithelial remodeling is a histopathologic feature of chronic inflammatory airway diseases including chronic rhinosinusitis (CRS). Cell-type shifts and their relationship to CRS endotypes and severity are incompletely described.<h4>Objective</h4>We sought to understand the relationship of epithelial cell remodeling to inflammatory endotypes and disease outcomes in CRS.<h4>Methods</h4>Using cell-type transcriptional signatures derived from epithelial single-cell sequencing, we analyzed bulk RNA-sequencing data from sinus epithelial brushings obtained from patients with CRS with and without nasal polyps in comparison to healthy controls.<h4>Results</h4>The airway epithelium in nasal polyposis displayed increased tuft cell transcripts and decreased ciliated cell transcripts","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 May","modification":"2025-04-19T07:21:43.207Z","creation":"2025-04-19T07:21:43.207Z"},"accession":"S-EPMC10243183","cross_references":{"pubmed":["36736797"],"doi":["10.1016/j.jaci.2022.12.826"]}}