biostudies-literatureKotas MENIAID NIH HHSNHLBI NIH HHS1277-1285https://www.ebi.ac.uk/biostudies/studies/S-EPMC10243183biostudies-literatureUnknown151(5)<h4>Background</h4>Epithelial remodeling is a histopathologic feature of chronic inflammatory airway diseases including chronic rhinosinusitis (CRS). Cell-type shifts and their relationship to CRS endotypes and severity are incompletely described.<h4>Objective</h4>We sought to understand the relationship of epithelial cell remodeling to inflammatory endotypes and disease outcomes in CRS.<h4>Methods</h4>Using cell-type transcriptional signatures derived from epithelial single-cell sequencing, we analyzed bulk RNA-sequencing data from sinus epithelial brushings obtained from patients with CRS with and without nasal polyps in comparison to healthy controls.<h4>Results</h4>The airway epithelium in nasal polyposis displayed increased tuft cell transcripts and decreased ciliated cell transcriptsThe Journal of allergy and clinical immunologyIL-13-associated epithelial remodeling correlates with clinical severity in nasal polyposis.PMC10243183F32 HL158174P01 HL107202R15 AI147148R01 HL135156P01 HL132821F32 HL140868R01 AI136962T32 HL007185R01 HL128439Gordon EDCope EKPletcher SDMoore CMPatel NNGurrola JGGoldberg ANKotas MESeibold MAfalseIL-13-associated epithelial remodeling correlates with clinical severity in nasal polyposis.<h4>Background</h4>Epithelial remodeling is a histopathologic feature of chronic inflammatory airway diseases including chronic rhinosinusitis (CRS). Cell-type shifts and their relationship to CRS endotypes and severity are incompletely described.<h4>Objective</h4>We sought to understand the relationship of epithelial cell remodeling to inflammatory endotypes and disease outcomes in CRS.<h4>Methods</h4>Using cell-type transcriptional signatures derived from epithelial single-cell sequencing, we analyzed bulk RNA-sequencing data from sinus epithelial brushings obtained from patients with CRS with and without nasal polyps in comparison to healthy controls.<h4>Results</h4>The airway epithelium in nasal polyposis displayed increased tuft cell transcripts and decreased ciliated cell transcripts2023-01-01T00:00:00Z2023 May2025-04-19T07:21:43.207Z2025-04-19T07:21:43.207ZS-EPMC102431833673679710.1016/j.jaci.2022.12.826