biostudies-literatureUnknown14Deng B<h4>Background</h4>Endoplasmic reticulum stress (ERS) is a critical factor in the development of ulcerative colitis (UC); however, the underlying molecular mechanisms remain unclear. This study aims to identify pivotal molecular mechanisms related to ERS in UC pathogenesis and provide novel therapeutic targets for UC.<h4>Methods</h4>Colon tissue gene expression profiles and clinical information of UC patients and healthy controls were obtained from the Gene Expression Omnibus (GEO) database, and the ERS-related gene set was downloaded from GeneCards for analysis. Weighted gene co-expression network analysis (WGCNA) and differential expression analysis were utilized to identify pivotal modules and genes associated with UC. A consensus clustering algorithm was used to classify UC patients. TFrontiers in immunology1158648https://www.ebi.ac.uk/biostudies/studies/S-EPMC10243217biostudies-literatureComprehensive analysis of endoplasmic reticulum stress-associated genes signature of ulcerative colitis.PMC10243217Deng BLiu YDong WLiao FWei SLiu CHe PfalseComprehensive analysis of endoplasmic reticulum stress-associated genes signature of ulcerative colitis.<h4>Background</h4>Endoplasmic reticulum stress (ERS) is a critical factor in the development of ulcerative colitis (UC); however, the underlying molecular mechanisms remain unclear. This study aims to identify pivotal molecular mechanisms related to ERS in UC pathogenesis and provide novel therapeutic targets for UC.<h4>Methods</h4>Colon tissue gene expression profiles and clinical information of UC patients and healthy controls were obtained from the Gene Expression Omnibus (GEO) database, and the ERS-related gene set was downloaded from GeneCards for analysis. Weighted gene co-expression network analysis (WGCNA) and differential expression analysis were utilized to identify pivotal modules and genes associated with UC. A consensus clustering algorithm was used to classify UC patients. T2023-01-01T00:00:00Z20232026-06-24T03:28:02.919Z2025-02-19T02:38:04.394ZS-EPMC102432173728798710.3389/fimmu.2023.1158648