{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Hu L"],"funding":["Scripps Research Institute","National Institute of General Medical Sciences","NIGMS NIH HHS"],"pagination":["20550-20553"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10243520"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["144(45)"],"pubmed_abstract":["Ligand development has enabled rapid advances in Pd(II)-catalyzed β-methyl C(sp<sup>3</sup>)-H activation of free carboxylic acids. However, there are only a handful of reports of free-acid-directed β-methylene C(sp<sup>3</sup>)-H activation, all of which are limited to intramolecular reactions. Herein, we report the first Pd(II)-catalyzed intermolecular β-methylene C(sp<sup>3</sup>)-H arylation of free aliphatic acids, which is enabled by bidentate pyridine-pyridone ligands. The bite angle of this ligand has been discovered to play a key role in promoting β-methylene C-H activation of free carboxylic acid. This new transformation provides a disconnection for alkylation of arenes with simple aliphatic acids. A variety of free aliphatic acids, including the antiasthmatic drug seratrodast, w"],"journal":["Journal of the American Chemical Society"],"pubmed_title":["Ligand-Enabled Pd(II)-Catalyzed β-Methylene C(sp<sup>3</sup>)-H Arylation of Free Aliphatic Acids."],"pmcid":["PMC10243520"],"funding_grant_id":["R01 GM084019","R01GM084019"],"pubmed_authors":["Yu JQ","Hu L","Meng G"],"additional_accession":[]},"is_claimable":false,"name":"Ligand-Enabled Pd(II)-Catalyzed β-Methylene C(sp<sup>3</sup>)-H Arylation of Free Aliphatic Acids.","description":"Ligand development has enabled rapid advances in Pd(II)-catalyzed β-methyl C(sp<sup>3</sup>)-H activation of free carboxylic acids. However, there are only a handful of reports of free-acid-directed β-methylene C(sp<sup>3</sup>)-H activation, all of which are limited to intramolecular reactions. Herein, we report the first Pd(II)-catalyzed intermolecular β-methylene C(sp<sup>3</sup>)-H arylation of free aliphatic acids, which is enabled by bidentate pyridine-pyridone ligands. The bite angle of this ligand has been discovered to play a key role in promoting β-methylene C-H activation of free carboxylic acid. This new transformation provides a disconnection for alkylation of arenes with simple aliphatic acids. A variety of free aliphatic acids, including the antiasthmatic drug seratrodast, w","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Nov","modification":"2025-04-04T21:13:51.647Z","creation":"2025-04-04T21:13:51.647Z"},"accession":"S-EPMC10243520","cross_references":{"pubmed":["36342466"],"doi":["10.1021/jacs.2c09205"]}}