{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Lubeck M"],"funding":["Deutsche Forschungsgemeinschaft"],"pagination":["e0286756"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10243636"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["18(6)"],"pubmed_abstract":["Impairments of mitochondrial functions are linked to human ageing and pathologies such as cancer, cardiomyopathy, neurodegeneration and diabetes. Specifically, aberrations in ultrastructure of mitochondrial inner membrane (IM) and factors regulating them are linked to diabetes. The development of diabetes is connected to the 'Mitochondrial Contact Site and Cristae Organising System' (MICOS) complex which is a large membrane protein complex defining the IM architecture. MIC26 and MIC27 are homologous apolipoproteins of the MICOS complex. MIC26 has been reported as a 22 kDa mitochondrial and a 55 kDa glycosylated and secreted protein. The molecular and functional relationship between these MIC26 isoforms has not been investigated. In order to understand their molecular roles, we depleted MIC"],"journal":["PloS one"],"pubmed_title":["MIC26 and MIC27 are bona fide subunits of the MICOS complex in mitochondria and do not exist as glycosylated apolipoproteins."],"pmcid":["PMC10243636"],"funding_grant_id":["DFG AN 1440/3-1","VIVID RTG2576 Project 3b","DFG KO 6519/1-1"],"pubmed_authors":["Driessen MD","Roden M","Kondadi AK","Belgardt BF","Anand R","Reichert AS","Lubeck M","Stuhler K","Derkum NH","Strohm R","Naha R"],"additional_accession":[]},"is_claimable":false,"name":"MIC26 and MIC27 are bona fide subunits of the MICOS complex in mitochondria and do not exist as glycosylated apolipoproteins.","description":"Impairments of mitochondrial functions are linked to human ageing and pathologies such as cancer, cardiomyopathy, neurodegeneration and diabetes. Specifically, aberrations in ultrastructure of mitochondrial inner membrane (IM) and factors regulating them are linked to diabetes. The development of diabetes is connected to the 'Mitochondrial Contact Site and Cristae Organising System' (MICOS) complex which is a large membrane protein complex defining the IM architecture. MIC26 and MIC27 are homologous apolipoproteins of the MICOS complex. MIC26 has been reported as a 22 kDa mitochondrial and a 55 kDa glycosylated and secreted protein. The molecular and functional relationship between these MIC26 isoforms has not been investigated. In order to understand their molecular roles, we depleted MIC","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023","modification":"2026-05-28T19:56:55.143Z","creation":"2025-02-19T02:37:59.44Z"},"accession":"S-EPMC10243636","cross_references":{"pubmed":["37279200"],"doi":["10.1371/journal.pone.0286756"]}}