biostudies-literatureRichardson CMNHLBI NIH HHSNIDCD NIH HHS111371https://www.ebi.ac.uk/biostudies/studies/S-EPMC10243723biostudies-literatureUnknown164<h4>Objectives</h4>Patients born with bilateral head and neck lymphatic malformations (BHNLMs) often require multiple invasive treatments, including tracheostomy. We hypothesized that primary targeted medical therapy (pTMT) with diagnostic needle aspiration reduces the need for invasive therapy such as surgical resection and/or sclerotherapy.<h4>Methods</h4>Retrospective case review was performed of infants with BHNLMs (Grade 2 or De Serres stage IV and V) treated only at our institution from 2000 to 2021. Patients were divided into two cohorts: those managed with pTMT and those managed with observation, sclerotherapy, or surgical intervention (non-pTMT). Data regarding interventions, clinical outcomes, morbidity, and mortality were analyzed with descriptive statistics.<h4>Results</h4>NineInternational journal of pediatric otorhinolaryngologyPrimary targeted medical therapy for management of bilateral head and neck lymphatic malformations in infants.PMC10243723F32 HL147398T32 DC000018R01 HL130996Richardson CMPerkins JNBennett JTWenger TLBly RAJensen DMLutsky EZenner KDmyterko VPerkins JABull CBonilla-Velez JDahl JPGeddis AEfalsePrimary targeted medical therapy for management of bilateral head and neck lymphatic malformations in infants.<h4>Objectives</h4>Patients born with bilateral head and neck lymphatic malformations (BHNLMs) often require multiple invasive treatments, including tracheostomy. We hypothesized that primary targeted medical therapy (pTMT) with diagnostic needle aspiration reduces the need for invasive therapy such as surgical resection and/or sclerotherapy.<h4>Methods</h4>Retrospective case review was performed of infants with BHNLMs (Grade 2 or De Serres stage IV and V) treated only at our institution from 2000 to 2021. Patients were divided into two cohorts: those managed with pTMT and those managed with observation, sclerotherapy, or surgical intervention (non-pTMT). Data regarding interventions, clinical outcomes, morbidity, and mortality were analyzed with descriptive statistics.<h4>Results</h4>Nine2023-01-01T00:00:00Z2023 Jan2025-06-01T01:18:16.764Z2025-06-01T01:18:16.764ZS-EPMC102437233645972510.1016/j.ijporl.2022.111371