biostudies-literaturePalmerini EDaiichi Sankyo, Inc.NCI NIH HHSe425-e435https://www.ebi.ac.uk/biostudies/studies/S-EPMC10243766biostudies-literatureUnknown28(6)<h4>Background</h4>The Tenosynovial giant cell tumor Observational Platform Project (TOPP) registry is an international prospective study that -previously described the impact of diffuse-type tenosynovial giant cell tumour (D-TGCT) on patient-reported outcomes (PROs) from a baseline snapshot. This analysis describes the impact of D-TGCT at 2-year follow-up based on treatment strategies.<h4>Material and methods</h4>TOPP was conducted at 12 sites (EU: 10; US: 2). Captured PRO measurements assessed at baseline, 1-year, and 2-year follow-ups were Brief Pain Inventory (BPI), Pain Interference, BPI Pain Severity, Worst Pain, EQ-5D-5L, Worst Stiffness, and -Patient-Reported Outcomes Measurement Information System. Treatment interventions were no current/planned treatment (Off-Treatment) and systeThe oncologistTenosynovial Giant Cell Tumor Observational Platform Project (TOPP) Registry: A 2-Year Analysis of Patient-Reported Outcomes and Treatment Strategies.PMC10243766P30 CA008748Schreuder Hvan de Sande MHealey JHGelderblom HPalmerini ELeithner AMercier FLaeis PLopez-Bastida JYe XBauer SMartin-Broto JBernthal NMGouin FStaals ELfalseTenosynovial Giant Cell Tumor Observational Platform Project (TOPP) Registry: A 2-Year Analysis of Patient-Reported Outcomes and Treatment Strategies.<h4>Background</h4>The Tenosynovial giant cell tumor Observational Platform Project (TOPP) registry is an international prospective study that -previously described the impact of diffuse-type tenosynovial giant cell tumour (D-TGCT) on patient-reported outcomes (PROs) from a baseline snapshot. This analysis describes the impact of D-TGCT at 2-year follow-up based on treatment strategies.<h4>Material and methods</h4>TOPP was conducted at 12 sites (EU: 10; US: 2). Captured PRO measurements assessed at baseline, 1-year, and 2-year follow-ups were Brief Pain Inventory (BPI), Pain Interference, BPI Pain Severity, Worst Pain, EQ-5D-5L, Worst Stiffness, and -Patient-Reported Outcomes Measurement Information System. Treatment interventions were no current/planned treatment (Off-Treatment) and syste2023-01-01T00:00:00Z2023 Jun2026-07-14T21:14:55.443Z2025-04-04T14:40:00.75ZS-EPMC102437663686979310.1093/oncolo/oyad011