biostudies-literatureUnknownAdams RLMedical Research Council<h4>Background</h4>Copy number variants (CNVs) have been associated with the risk of schizophrenia, autism and intellectual disability. However, little is known about their spectrum of psychopathology in adulthood.<h4>Methods</h4>We investigated the psychiatric phenotypes of adult CNV carriers and compared probands, who were ascertained through clinical genetics services, with carriers who were not. One hundred twenty-four adult participants (age 18-76), each bearing one of 15 rare CNVs, were recruited through a variety of sources including clinical genetics services, charities for carriers of genetic variants, and online advertising. A battery of psychiatric assessments was used to determine psychopathology.<h4>Results</h4>The frequencies of psychopathology were consistently higher for thPsychological medicine1-8https://www.ebi.ac.uk/biostudies/studies/S-EPMC10244007biostudies-literaturePsychopathology in adults with copy number variants.PMC10244007MR/L010305/1Adams RLOwen MJBaird AWilliams NLinden DEJLinden SCHall Jvan den Bree MBMSmith JfalsePsychopathology in adults with copy number variants.<h4>Background</h4>Copy number variants (CNVs) have been associated with the risk of schizophrenia, autism and intellectual disability. However, little is known about their spectrum of psychopathology in adulthood.<h4>Methods</h4>We investigated the psychiatric phenotypes of adult CNV carriers and compared probands, who were ascertained through clinical genetics services, with carriers who were not. One hundred twenty-four adult participants (age 18-76), each bearing one of 15 rare CNVs, were recruited through a variety of sources including clinical genetics services, charities for carriers of genetic variants, and online advertising. A battery of psychiatric assessments was used to determine psychopathology.<h4>Results</h4>The frequencies of psychopathology were consistently higher for th2022-01-01T00:00:00Z2022 Feb2025-04-19T08:11:26.384Z2025-04-19T08:11:26.384ZS-EPMC102440073514470910.1017/S0033291721005201