{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Jee YH"],"funding":["National Cancer Institute","NCI NIH HHS","National Institutes of Health"],"pagination":["796-805"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10244045"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["52(3)"],"pubmed_abstract":["<h4>Background</h4>Polygenic risk scores (PRSs) for breast cancer, developed using European and Asian genome-wide association studies (GWAS), have been shown to have good discrimination in Asian women. However, prospective calibration of absolute risk prediction models, based on a PRS or PRS combined with lifestyle, clinical and environmental factors, in Asian women is limited.<h4>Methods</h4>We consider several PRSs trained using European and/or Asian GWAS. For each PRS, we evaluate the discrimination and calibration of three absolute risk models among 41 031 women from the Korean Cancer Prevention Study (KCPS)-II Biobank: (i) a model using incidence, mortality and risk factor distributions (reference inputs) among US women and European relative risks; (ii) a recalibrated model, using Korean reference but European relative risks; and (iii) a fully Korean-based model using Korean reference and relative risk estimates from KCPS.<h4>Results</h4>All Asian and European PRS improved discrimination over lifestyle, clinical and environmental (Qx) factors in Korean women. US-based absolute risk models overestimated the risks for women aged ≥50 years, and this overestimation was larger for models that only included PRS (expected-to-observed ratio E/O = 1.2 for women <50, E/O = 2.7 for women ≥50). Recalibrated and Korean-based risk models had better calibration in the large, although the risk in the highest decile was consistently overestimated. Absolute risk projections suggest that risk-reducing lifestyle changes would lead to larger absolute risk reductions among women at higher PRS.<h4>Conclusions</h4>Absolute risk models incorporating PRS trained in European and Asian GWAS and population-appropriate average age-specific incidences may be useful for risk-stratified interventions in Korean women."],"journal":["International journal of epidemiology"],"pubmed_title":["Polygenic risk scores for prediction of breast cancer in Korean women."],"pmcid":["PMC10244045"],"funding_grant_id":["U01 CA261339","U01 CA249866"],"pubmed_authors":["Jee YH","Ho WK","Easton DF","Jung KJ","Kraft P","Park S","Teo SH"],"additional_accession":[]},"is_claimable":false,"name":"Polygenic risk scores for prediction of breast cancer in Korean women.","description":"<h4>Background</h4>Polygenic risk scores (PRSs) for breast cancer, developed using European and Asian genome-wide association studies (GWAS), have been shown to have good discrimination in Asian women. However, prospective calibration of absolute risk prediction models, based on a PRS or PRS combined with lifestyle, clinical and environmental factors, in Asian women is limited.<h4>Methods</h4>We consider several PRSs trained using European and/or Asian GWAS. For each PRS, we evaluate the discrimination and calibration of three absolute risk models among 41 031 women from the Korean Cancer Prevention Study (KCPS)-II Biobank: (i) a model using incidence, mortality and risk factor distributions (reference inputs) among US women and European relative risks; (ii) a recalibrated model, using Korean reference but European relative risks; and (iii) a fully Korean-based model using Korean reference and relative risk estimates from KCPS.<h4>Results</h4>All Asian and European PRS improved discrimination over lifestyle, clinical and environmental (Qx) factors in Korean women. US-based absolute risk models overestimated the risks for women aged ≥50 years, and this overestimation was larger for models that only included PRS (expected-to-observed ratio E/O = 1.2 for women <50, E/O = 2.7 for women ≥50). Recalibrated and Korean-based risk models had better calibration in the large, although the risk in the highest decile was consistently overestimated. Absolute risk projections suggest that risk-reducing lifestyle changes would lead to larger absolute risk reductions among women at higher PRS.<h4>Conclusions</h4>Absolute risk models incorporating PRS trained in European and Asian GWAS and population-appropriate average age-specific incidences may be useful for risk-stratified interventions in Korean women.","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Jun","modification":"2025-04-21T17:24:31.161Z","creation":"2025-04-05T16:23:48.406Z"},"accession":"S-EPMC10244045","cross_references":{"pubmed":["36343017"],"doi":["10.1093/ije/dyac206"]}}