{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["15"],"submitter":["Yadav Y"],"pubmed_abstract":["<h4>Introduction</h4>Geometry-inspired notions of discrete Ricci curvature have been successfully used as markers of disrupted brain connectivity in neuropsychiatric disorders, but their ability to characterize age-related changes in functional connectivity is unexplored.<h4>Methods</h4>We apply Forman-Ricci curvature and Ollivier-Ricci curvature to compare functional connectivity networks of healthy young and older subjects from the Max Planck Institute Leipzig Study for Mind-Body-Emotion Interactions (MPI-LEMON) dataset (<i>N</i> = 225).<h4>Results</h4>We found that both Forman-Ricci curvature and Ollivier-Ricci curvature can capture whole-brain and region-level age-related differences in functional connectivity. Meta-analysis decoding demonstrated that those brain regions with age-relat"],"journal":["Frontiers in aging neuroscience"],"pagination":["1120846"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10244515"],"repository":["biostudies-literature"],"pubmed_title":["Discrete Ricci curvatures capture age-related changes in human brain functional connectivity networks."],"pmcid":["PMC10244515"],"pubmed_authors":["Elumalai P","Williams N","Samal A","Yadav Y","Jost J"],"additional_accession":[]},"is_claimable":false,"name":"Discrete Ricci curvatures capture age-related changes in human brain functional connectivity networks.","description":"<h4>Introduction</h4>Geometry-inspired notions of discrete Ricci curvature have been successfully used as markers of disrupted brain connectivity in neuropsychiatric disorders, but their ability to characterize age-related changes in functional connectivity is unexplored.<h4>Methods</h4>We apply Forman-Ricci curvature and Ollivier-Ricci curvature to compare functional connectivity networks of healthy young and older subjects from the Max Planck Institute Leipzig Study for Mind-Body-Emotion Interactions (MPI-LEMON) dataset (<i>N</i> = 225).<h4>Results</h4>We found that both Forman-Ricci curvature and Ollivier-Ricci curvature can capture whole-brain and region-level age-related differences in functional connectivity. Meta-analysis decoding demonstrated that those brain regions with age-relat","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023","modification":"2025-04-27T02:20:22.658Z","creation":"2025-04-06T18:31:03.058Z"},"accession":"S-EPMC10244515","cross_references":{"pubmed":["37293668"],"doi":["10.3389/fnagi.2023.1120846"]}}