biostudies-literatureUnknown15Yadav Y<h4>Introduction</h4>Geometry-inspired notions of discrete Ricci curvature have been successfully used as markers of disrupted brain connectivity in neuropsychiatric disorders, but their ability to characterize age-related changes in functional connectivity is unexplored.<h4>Methods</h4>We apply Forman-Ricci curvature and Ollivier-Ricci curvature to compare functional connectivity networks of healthy young and older subjects from the Max Planck Institute Leipzig Study for Mind-Body-Emotion Interactions (MPI-LEMON) dataset (<i>N</i> = 225).<h4>Results</h4>We found that both Forman-Ricci curvature and Ollivier-Ricci curvature can capture whole-brain and region-level age-related differences in functional connectivity. Meta-analysis decoding demonstrated that those brain regions with age-relatFrontiers in aging neuroscience1120846https://www.ebi.ac.uk/biostudies/studies/S-EPMC10244515biostudies-literatureDiscrete Ricci curvatures capture age-related changes in human brain functional connectivity networks.PMC10244515Elumalai PWilliams NSamal AYadav YJost JfalseDiscrete Ricci curvatures capture age-related changes in human brain functional connectivity networks.<h4>Introduction</h4>Geometry-inspired notions of discrete Ricci curvature have been successfully used as markers of disrupted brain connectivity in neuropsychiatric disorders, but their ability to characterize age-related changes in functional connectivity is unexplored.<h4>Methods</h4>We apply Forman-Ricci curvature and Ollivier-Ricci curvature to compare functional connectivity networks of healthy young and older subjects from the Max Planck Institute Leipzig Study for Mind-Body-Emotion Interactions (MPI-LEMON) dataset (<i>N</i> = 225).<h4>Results</h4>We found that both Forman-Ricci curvature and Ollivier-Ricci curvature can capture whole-brain and region-level age-related differences in functional connectivity. Meta-analysis decoding demonstrated that those brain regions with age-relat2023-01-01T00:00:00Z20232025-04-27T02:20:22.658Z2025-04-06T18:31:03.058ZS-EPMC102445153729366810.3389/fnagi.2023.1120846