{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"submitter":["Shourkeshti A"],"funding":["Natural Sciences and Engineering Research Council of Canada","NEI NIH HHS","National Eye Institute","Fonds de Recherche du Québec–Santé","Jacobs Foundation","CIFAR Azrieli Global Scholars","l’Institut de valorisation des données"],"pubmed_abstract":["In uncertain environments, intelligent decision-makers exploit actions that have been rewarding in the past, but also explore actions that could be even better. Several neuromodulatory systems are implicated in exploration, based, in part, on work linking exploration to pupil size-a peripheral correlate of neuromodulatory tone and index of arousal. However, pupil size could instead track variables that make exploration more likely, like volatility or reward, without directly predicting either exploration or its neural bases. Here, we simultaneously measured pupil size, exploration, and neural population activity in the prefrontal cortex while two rhesus macaques explored and exploited in a dynamic environment. We found that pupil size under constant luminance specifically predicted the ons"],"journal":["bioRxiv : the preprint server for biology"],"pagination":["2023.05.24.541981"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10245915"],"repository":["biostudies-literature"],"pubmed_title":["Pupil size predicts the onset of exploration and changes in prefrontal dynamics."],"pmcid":["PMC10245915"],"funding_grant_id":["Discovery Grant RGPIN-2020-05577","Junior 1 Chercheur-Boursier 284309 to R.B.E","R01-EY014924 to T.M","R01 EY014924"],"pubmed_authors":["Jurewicz K","Abbaszadeh M","Ebitz RB","Shourkeshti A","Marrocco G","Moore T"],"additional_accession":[]},"is_claimable":false,"name":"Pupil size predicts the onset of exploration and changes in prefrontal dynamics.","description":"In uncertain environments, intelligent decision-makers exploit actions that have been rewarding in the past, but also explore actions that could be even better. Several neuromodulatory systems are implicated in exploration, based, in part, on work linking exploration to pupil size-a peripheral correlate of neuromodulatory tone and index of arousal. However, pupil size could instead track variables that make exploration more likely, like volatility or reward, without directly predicting either exploration or its neural bases. Here, we simultaneously measured pupil size, exploration, and neural population activity in the prefrontal cortex while two rhesus macaques explored and exploited in a dynamic environment. We found that pupil size under constant luminance specifically predicted the ons","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Aug","modification":"2026-06-05T03:26:06.673Z","creation":"2026-06-05T03:11:57.945Z"},"accession":"S-EPMC10245915","cross_references":{"pubmed":["37292773"],"doi":["10.1101/2023.05.24.541981"]}}