{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Mortensen KT"],"funding":["Carlsbergfondet","Ny Carlsbergfondet","Royal Society","UK Research and Innovation","Biotechnology and Biological Sciences Research Council","Engineering and Physical Sciences Research Council"],"pagination":["4591-4595"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10246434"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["21(22)"],"pubmed_abstract":["Fragment-based lead discovery (FBLD) often relies on flat, aromatic compounds which display undesirable physicochemical properties with limited exit vectors for fragment growth. Herein, we report concise synthetic strategies to sp<sup>3</sup>-rich heterocyclic fragments encompassing polar exit vectors poised for fragment-to-lead (F2L) development."],"journal":["Organic & biomolecular chemistry"],"pubmed_title":["Synthesis of sp<sup>3</sup>-rich heterocyclic frameworks by a divergent synthesis strategy."],"pmcid":["PMC10246434"],"funding_grant_id":["EP/P020291/1"],"pubmed_authors":["Wong DSY","Spring DR","Mortensen KT","King TA","Sore HF"],"additional_accession":[]},"is_claimable":false,"name":"Synthesis of sp<sup>3</sup>-rich heterocyclic frameworks by a divergent synthesis strategy.","description":"Fragment-based lead discovery (FBLD) often relies on flat, aromatic compounds which display undesirable physicochemical properties with limited exit vectors for fragment growth. Herein, we report concise synthetic strategies to sp<sup>3</sup>-rich heterocyclic fragments encompassing polar exit vectors poised for fragment-to-lead (F2L) development.","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Jun","modification":"2025-04-04T08:06:50.811Z","creation":"2025-04-04T08:06:50.811Z"},"accession":"S-EPMC10246434","cross_references":{"pubmed":["37203457"],"doi":["10.1039/d3ob00351e"]}}