biostudies-literatureRice BANCATS NIH HHSNIDDK NIH HHSNHLBI NIH HHS2854-2863.e2https://www.ebi.ac.uk/biostudies/studies/S-EPMC10247898biostudies-literatureUnknown21(11)<h4>Background and aims</h4>While heavy alcohol use consistently associates with liver disease, the effects of nonheavy alcohol consumption are less understood. We aimed to investigate the relationship between nonheavy alcohol use and chronic liver disease.<h4>Methods</h4>This cross-sectional study included 2629 current drinkers in the Framingham Heart Study who completed alcohol use questionnaires and transient elastography. We defined fibrosis as liver stiffness measurement (LSM) ≥8.2 kPa. We defined at-risk nonalcoholic steatohepatitis (NASH) as FibroScan-aspartate aminotransferase (FAST) score >0.35 (90% sensitivity) or ≥0.67 (90% specificity). We performed logistic regression to investigate associations of alcohol use measures with fibrosis and NASH, adjusting for sociodemographic andClinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological AssociationNonheavy Alcohol Use Associates With Liver Fibrosis and Nonalcoholic Steatohepatitis in the Framingham Heart Study.PMC10247898HHSN268201500001CUL1 TR001430K23 DK11325275N92019D00031HHSN268201500001IN01HC25195Naimi TSRice BALong MTfalseNonheavy Alcohol Use Associates With Liver Fibrosis and Nonalcoholic Steatohepatitis in the Framingham Heart Study.<h4>Background and aims</h4>While heavy alcohol use consistently associates with liver disease, the effects of nonheavy alcohol consumption are less understood. We aimed to investigate the relationship between nonheavy alcohol use and chronic liver disease.<h4>Methods</h4>This cross-sectional study included 2629 current drinkers in the Framingham Heart Study who completed alcohol use questionnaires and transient elastography. We defined fibrosis as liver stiffness measurement (LSM) ≥8.2 kPa. We defined at-risk nonalcoholic steatohepatitis (NASH) as FibroScan-aspartate aminotransferase (FAST) score >0.35 (90% sensitivity) or ≥0.67 (90% specificity). We performed logistic regression to investigate associations of alcohol use measures with fibrosis and NASH, adjusting for sociodemographic and2023-01-01T00:00:00Z2023 Oct2025-04-04T18:52:30.16Z2025-04-04T18:52:30.16ZS-EPMC102478983650316710.1016/j.cgh.2022.10.039