{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Jones SE"],"funding":["Instrumentariumin Tiedesäätiö","British Heart Foundation","Signe ja Ane Gyllenbergin Säätiö","Cancer Research UK","NIAID NIH HHS","NHLBI NIH HHS","National Institutes of Health","Scottish Government","Academy of Finland","Northwest Regional Development Agency","NIDDK NIH HHS","Medical Research Council","National Institute for Health Research (NIHR)","Wellcome Trust"],"pagination":["104630"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10248098"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["93"],"pubmed_abstract":["<h4>Background</h4>Poor sleep is associated with an increased risk of infections and all-cause mortality but the causal direction between poor sleep and respiratory infections has remained unclear. We examined if poor sleep contributes as a causal risk factor to respiratory infections.<h4>Methods</h4>We used data on insomnia, influenza and upper respiratory infections (URIs) from primary care and hospital records in the UK Biobank (N ≈ 231,000) and FinnGen (N ≈ 392,000). We computed logistic regression to assess association between poor sleep and infections, disease free survival hazard ratios, and performed Mendelian randomization analyses to assess causality.<h4>Findings</h4>Utilizing 23 years of registry data and follow-up, we discovered that insomnia diagnosis associated with increased"],"journal":["EBioMedicine"],"pubmed_title":["The public health impact of poor sleep on severe COVID-19, influenza and upper respiratory infections."],"pmcid":["PMC10248098"],"funding_grant_id":["R35 HL135818","K01HL136884","1R01HL146751","R35135818","340539","R01HL153805","R01 DK107859","R01 HL153805","R01 AI170850","1R01AI170850"],"pubmed_authors":["Lahteenmaki S","Helminen M","Kaprio J","Biswas S","Estrada K","Hu X","Harju T","Pendergrass R","Obeidat ME","Smaoui N","John S","Blomster T","Arvas M","FinnGen","Vahatalo I","Toivola A","Hart A","Bing N","Laitinen T","Rodosthenous R","Gracia-Tabuenca J","Addis L","Bowers N","Abbasi A","Ziemann A","Ngo D","Makela 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J","Jones SE","Koskela J","Jacob H","Paul D","Pelkonen M","Kulkarni D","Bizaki-Vallaskangas A","Hakanen A","Niemi M","Havulinna A","Kahonen M","Chen H","Tienari P","Raivio T","Sul JH","Tasanen K","Siltanen S","Wahlfors T","Auvinen P","Kuopio T","Strausz S","Rinne J","Raivio M","Teng E","Kaarniranta K","Valimaki N","Loboda A","Virolainen P","Plenge R","Liu M","Rivas M","Pylkas K","Sliz E","Tyrmi J","Maasha M","Klinger K","Mannikko L","Schutzman J","Uusitalo H","Ehm MG","O Donnell C","Mantere T","Palomaki A","Anttonen V","Broberg ME","Ghazal A","Strauss E","Della Briotta Parolo P","Hovatta I","Sipila TP","Parn K","Saarentaus E","Kallio L","Auro K","Heyne H","Guan M","Lessard S","Luukkaala T","Hinttala R","Porello A","Lehto P","Liu A","Sinisalo J","Mannermaa A","Luo S","Julkunen V","Kangasniemi E","Punkka E","Farkkila M","Mendelson M","Kivinen K","Tammerluoto J","Daly M","Lemmela S","Lahesmaa R","Pulford D","Palotie A","Sistonen T","Mars N","Fabre M","Laivuori H","Viollet C","Als TD","Vaura F","Huilaja L","Laakkonen E","Ollila HM","Aalto-Setala K","Kalpala K","McCarthy M","Zheng Z","Makela J","Palotie U","Palotie T","McCarthy L","Partanen J","Redline S","Lertratanakul A","Hernesniemi J","Aaltonen L","Laiho P","Kanai M","Laukkanen M","Laukkanen J","Okafo G","Mattson J","Makitie A","Rice D","Pirila L","Isomaki P","Jussila A","Pakkanen R","Runz H","Arffman R","Salomaa V","Lee J","Brunfeldt M","Strausz SJ","Shen HY","Salo T","Chu A","Serpi R","Maisha FI","Loomis S","Maranville J","Kurra V","Kilpi T","McDonough S","Jokimaa V","Lahtela LE","Kaunisto M","Huhtakangas J","Khramtsova E","Karjalainen M","Karjalainen J","Jalanko A","Vaarasmaki M","Pitkaranta A","Zhou W","Eklund K","Ramo J","Malarstig A","Peltonen S","Hautalahti M","Chatelain C","Jung M","Renaud N","Nieminen P","Tukiainen T","Aavikko M","Pitkanen E","Isometsa E","Kosma VM","Suvisaari J","Dada OA","Salminen-Mankonen H","Kankaanranta H","Vuoti S","Peltola J","Pikkarainen S","Rahimov F","Niinimaki M","Llorens 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infections.","description":"<h4>Background</h4>Poor sleep is associated with an increased risk of infections and all-cause mortality but the causal direction between poor sleep and respiratory infections has remained unclear. We examined if poor sleep contributes as a causal risk factor to respiratory infections.<h4>Methods</h4>We used data on insomnia, influenza and upper respiratory infections (URIs) from primary care and hospital records in the UK Biobank (N ≈ 231,000) and FinnGen (N ≈ 392,000). We computed logistic regression to assess association between poor sleep and infections, disease free survival hazard ratios, and performed Mendelian randomization analyses to assess causality.<h4>Findings</h4>Utilizing 23 years of registry data and follow-up, we discovered that insomnia diagnosis associated with increased","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Jul","modification":"2026-07-14T16:59:05.801Z","creation":"2025-04-06T18:30:00.929Z"},"accession":"S-EPMC10248098","cross_references":{"pubmed":["37301713"],"doi":["10.1016/j.ebiom.2023.104630"]}}