biostudies-literatureJones SEInstrumentariumin TiedesäätiöBritish Heart FoundationSigne ja Ane Gyllenbergin SäätiöCancer Research UKNIAID NIH HHSNHLBI NIH HHSNational Institutes of HealthScottish GovernmentAcademy of FinlandNorthwest Regional Development AgencyNIDDK NIH HHSMedical Research CouncilNational Institute for Health Research (NIHR)Wellcome Trust104630https://www.ebi.ac.uk/biostudies/studies/S-EPMC10248098biostudies-literatureUnknown93<h4>Background</h4>Poor sleep is associated with an increased risk of infections and all-cause mortality but the causal direction between poor sleep and respiratory infections has remained unclear. We examined if poor sleep contributes as a causal risk factor to respiratory infections.<h4>Methods</h4>We used data on insomnia, influenza and upper respiratory infections (URIs) from primary care and hospital records in the UK Biobank (N ≈ 231,000) and FinnGen (N ≈ 392,000). We computed logistic regression to assess association between poor sleep and infections, disease free survival hazard ratios, and performed Mendelian randomization analyses to assess causality.<h4>Findings</h4>Utilizing 23 years of registry data and follow-up, we discovered that insomnia diagnosis associated with increasedEBioMedicineThe public health impact of poor sleep on severe COVID-19, influenza and upper respiratory infections.PMC10248098R35 HL135818K01HL1368841R01HL146751R35135818340539R01HL153805R01 DK107859R01 HL153805R01 AI1708501R01AI170850Lahteenmaki SHelminen MKaprio JBiswas SEstrada KHu XHarju TPendergrass RObeidat MESmaoui NJohn SBlomster TArvas MFinnGenVahatalo IToivola AHart ABing NLaitinen TRodosthenous RGracia-Tabuenca JAddis LBowers NAbbasi AZiemann ANgo DMakela TPMeretoja TKalliala IXu FHe KAberg FJoensuu HLawless NSuominen LSiirtola HSoininen HTachmazidou IMehtonen JTuomi TOllila TKarihtala PMiller MLeinonen RSaxena RMiller JSipila KSavukoski SRipatti SRiley-Gills BSalminen EUimari OTurunen JAGursoy UKytola ADonner KLammi VWiden EHuertas-Vazquez AReilly DSchleutker JPiltonen THiekkalinna TKettunen JFarias FMishra RWong RHeikinheimo OGanna ALinna MMHelaakoski VHochfeld MSalminen ATikkanen JToppila-Salmi SGossel MOllila HKristiansson KSilven HWillberg TKotaniemi-Talonen LElenius KPopovic RLoukola APerola MReeve MPJarvensivu ERemes ATuovila OWaring JKoskelainen SMantyla PTsuo KRaghavan NHedman ALongerich SHassan SKilpelainen EAarnisalo APaajanen TPalin KParkkinen JChen CYPujol NPalin HWeldatsadik RBetts JJones SEKoskela JJacob HPaul DPelkonen MKulkarni DBizaki-Vallaskangas AHakanen ANiemi MHavulinna AKahonen MChen HTienari PRaivio TSul JHTasanen KSiltanen SWahlfors TAuvinen PKuopio TStrausz SRinne JRaivio MTeng EKaarniranta KValimaki NLoboda AVirolainen PPlenge RLiu MRivas MPylkas KSliz ETyrmi JMaasha MKlinger KMannikko LSchutzman JUusitalo HEhm MGO Donnell CMantere TPalomaki AAnttonen VBroberg MEGhazal AStrauss EDella Briotta Parolo PHovatta ISipila TPParn KSaarentaus EKallio LAuro KHeyne HGuan MLessard SLuukkaala THinttala RPorello ALehto PLiu ASinisalo JMannermaa ALuo SJulkunen VKangasniemi EPunkka EFarkkila MMendelson MKivinen KTammerluoto JDaly MLemmela SLahesmaa RPulford DPalotie ASistonen TMars NFabre MLaivuori HViollet CAls TDVaura FHuilaja LLaakkonen EOllila HMAalto-Setala KKalpala KMcCarthy MZheng ZMakela JPalotie UPalotie TMcCarthy LPartanen JRedline SLertratanakul AHernesniemi JAaltonen LLaiho PKanai MLaukkanen MLaukkanen JOkafo GMattson JMakitie ARice DPirila LIsomaki PJussila APakkanen RRunz HArffman RSalomaa VLee JBrunfeldt MStrausz SJShen HYSalo TChu ASerpi RMaisha FILoomis SMaranville JKurra VKilpi TMcDonough SJokimaa VLahtela LEKaunisto MHuhtakangas JKhramtsova EKarjalainen MKarjalainen JJalanko AVaarasmaki MPitkaranta AZhou WEklund KRamo JMalarstig APeltonen SHautalahti MChatelain CJung MRenaud NNieminen PTukiainen TAavikko MPitkanen EIsometsa EKosma VMSuvisaari JDada OASalminen-Mankonen HKankaanranta HVuoti SPeltola JPikkarainen SRahimov FNiinimaki MLlorens VSoutherington TNiiranen TMetsarinne KAittomaki KElliott AWu YPitkanen NEaton SKurki MPadmanabhuni SSGordillo JERitari JTaskinen MRHeikkinen SVoutilainen MHiltunen TRiley-Gillis BAittokallio JGraham RHiltunen MEicher JMouded MKiiskinen TLu TPetrovski SYang RHannula-Jouppi KKauppi PGordin DSiponen MKaukinen KAuranen ALane JMLehtonen ALahdenpera SChoy DLehisto ARahikkala EMorin-Papunen LLehtonen HCarpen OHyvarinen KLi QSWaterworth DDing ZLaisk TSalmi TKaipiainen-Seppanen OKiviniemi MKaiharju EKalviainen RKoulu LRuotsalainen SKals MKajanne RCade BESmith SKumar JTervi APalta PKallionpaa RPussinen PGarcia-Tabuenca JMattsson HfalseThe public health impact of poor sleep on severe COVID-19, influenza and upper respiratory infections.<h4>Background</h4>Poor sleep is associated with an increased risk of infections and all-cause mortality but the causal direction between poor sleep and respiratory infections has remained unclear. We examined if poor sleep contributes as a causal risk factor to respiratory infections.<h4>Methods</h4>We used data on insomnia, influenza and upper respiratory infections (URIs) from primary care and hospital records in the UK Biobank (N ≈ 231,000) and FinnGen (N ≈ 392,000). We computed logistic regression to assess association between poor sleep and infections, disease free survival hazard ratios, and performed Mendelian randomization analyses to assess causality.<h4>Findings</h4>Utilizing 23 years of registry data and follow-up, we discovered that insomnia diagnosis associated with increased2023-01-01T00:00:00Z2023 Jul2026-07-14T16:59:05.801Z2025-04-06T18:30:00.929ZS-EPMC102480983730171310.1016/j.ebiom.2023.104630