biostudies-literatureZhang WFaculty of Science, Cairo UniversityU.S. Department of AgricultureScience and Technology Program of Guizhou ProvinceNational Natural Science Foundation of ChinaChongqing Normal UniversityNational Institute of Food and AgricultureNational Key Research and Development Program of ChinaInstitute of Food and Agricultural Sciences, University of Florida1-16https://www.ebi.ac.uk/biostudies/studies/S-EPMC10248801biostudies-literatureUnknown48<h4>Introduction</h4>Odorant-binding proteins (OBPs) are a class of small molecular weight soluble proteins that exist as expanded gene families in all insects, acting as ligand carriers mediating olfaction and other physiological processes. During fungal infection, a subset of insect OBPs were shown to be differentially expressed.<h4>Objectives</h4>We tested whether the altered expression of insect OBPs during pathogenic infection plays a role in behavioral or immune interactions between insect hosts and their pathogens.<h4>Methods</h4>A wide range of techniques including RNAi-directed knockdown, heterologous protein expression, electrophysiological/behavioral analyses, transcriptomics, gut microbiome analyses, coupled with tandem mass spectrometry ion monitoring, were used to characterizJournal of advanced researchAn odorant binding protein is involved in counteracting detection-avoidance and Toll-pathway innate immunity.PMC102488012019-0515032111530121320019612017YFD02012083216066631540089Zhang WKeyhani NOXia YZang LSSong BJia CMohamed ACao YXie MEleftherianos IBian JfalseAn odorant binding protein is involved in counteracting detection-avoidance and Toll-pathway innate immunity.<h4>Introduction</h4>Odorant-binding proteins (OBPs) are a class of small molecular weight soluble proteins that exist as expanded gene families in all insects, acting as ligand carriers mediating olfaction and other physiological processes. During fungal infection, a subset of insect OBPs were shown to be differentially expressed.<h4>Objectives</h4>We tested whether the altered expression of insect OBPs during pathogenic infection plays a role in behavioral or immune interactions between insect hosts and their pathogens.<h4>Methods</h4>A wide range of techniques including RNAi-directed knockdown, heterologous protein expression, electrophysiological/behavioral analyses, transcriptomics, gut microbiome analyses, coupled with tandem mass spectrometry ion monitoring, were used to characteriz2023-01-01T00:00:00Z2023 Jun2025-04-27T02:24:09.082Z2025-04-06T18:31:36.414ZS-EPMC102488013606418110.1016/j.jare.2022.08.013