{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Lindstrom S"],"funding":["Ministère de l’Économie, de la Science et de l”Innovation du Québec","Cancer Research UK","Johns Hopkins University","NIA NIH HHS","NIEHS NIH HHS","NIMH NIH HHS","National Institutes of Environmental Health Sciences","NHLBI NIH HHS","National Institutes of Health","NCI Cancer Center Support","National Institute on Aging","Canadian Institutes of Health Research","CCR NIH HHS","Scientific Computing Infrastructure at Fred Hutch","European Research Council","U.S. Department of Health and Human Services","Government of Canada","National Cancer Institute","Ontario Research Fund","NIH HHS","World Health Organization","NIDA NIH HHS","NIH","European Union","Center for Inherited Disease Research","NCI NIH HHS","Genome Québec","Genome Canada","Wellcome Trust"],"pagination":["712-732"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10248849"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["115(6)"],"pubmed_abstract":["<h4>Background</h4>The shared inherited genetic contribution to risk of different cancers is not fully known. In this study, we leverage results from 12 cancer genome-wide association studies (GWAS) to quantify pairwise genome-wide genetic correlations across cancers and identify novel cancer susceptibility loci.<h4>Methods</h4>We collected GWAS summary statistics for 12 solid cancers based on 376 759 participants with cancer and 532 864 participants without cancer of European ancestry. The included cancer types were breast, colorectal, endometrial, esophageal, glioma, head and neck, lung, melanoma, ovarian, pancreatic, prostate, and renal cancers. We conducted cross-cancer GWAS and transcriptome-wide association studies to discover novel cancer susceptibility loci. Finally, we assessed th"],"journal":["Journal of the National Cancer Institute"],"pubmed_title":["Genome-wide analyses characterize shared heritability among cancers and identify novel cancer susceptibility regions."],"pmcid":["PMC10248849"],"funding_grant_id":["U01 CA137088","R01 MH101814","P01 CA196569","R01 CA197350","C1287/A10118","C1287/A10710","R01 MH101819","090532","R21 CA191312","P30 CA014089","HHSN261200800001E","R01 MH101810","HHSN261200800001C","U19 CA148065","X01HG007492","4584","U01 CA122839","American Institute for Cancer Research","H2020 633784","R01 CA081488","076113","25514","R01 CA194393","R01 CA81488","001","U01 CA261339","S10OD028685","P30 CA015083","U01 CA182883","R01 DA006227","R01 CA242218","R01 MH090937","R01 MH090936","U01 AG18033","P30 CA008748","T32 ES013678","C1287/A16563","U01 CA167551","HHSN268201700006I","R01 CA189184","HHSN268201200008I","R01 MH090941","CRCPJT\\100025","S10 OD028685","R01 MH090948","R01 CA059045","232997","HHSN268201200008C","R35 CA197449","U01 CA164930","R01 CA201407","U19 CA148107","P30 CA015704","R01 MH101825","634935","294576","R01 CA143237","U01 CA206110","HHSN268201000029C","29017","R01 MH090951","R01 MH101820","R01 MH101822","R01201407","U19 CA203654","R01 MH101782","PSR-SIIRI-701","U01 AG018033"],"pubmed_authors":["Endometrial Cancer Association Consortium (ECAC)","Pancreatic Cancer Cohort Consortium (Panscan)","Melin B","Bishop DT","Scelo G","Christiani DC","Offit K","Wang L","Le Marchand L","Amos CI","Goldstein AM","Aldrich MC","Gharahkhani P","Schumacher J","Mckay J","Gunter MJ","Stolzenberg-Solomon R","Chanock SJ","Kar S","Brennan P","Fitzgerald R","International Lung Cancer Consortium (ILCCO)","Risch H","Breast Cancer Association Consortium (BCAC)","Chen H","Bammler T","Gruber SB","Pasaniuc B","Wolpin BM","Landi MT","Feng H","Amundadottir LT","Pharoah P","O'Mara TA","Huo S","Pancreatic Cancer Case-Control Consortium (Panc4), The PRACTICAL Consortium","Kraft P","Houlston RS","Macgregor S","Majumdar A","Harrison T","Law MH","Ovarian Cancer Association Consortium (OCAC)","Bondy ML","Demenais F","Kanetsky PA","Gockel I","Petersen G","Tomlinson I","Macdonald J","Gallinger S","Hung RJ","Iles MM","Jenkins RB","Mancuso N","Colorectal Transdisciplinary Study (CORECT), Colon Cancer Family Registry Study (CCFR), Genetics And Epidemiology Of Colorectal Cancer Consortium (GECCO)","De Vivo I","Jankowski J","Tardon A","Purdue MP","Spurdle AB","Barnholtz-Sloan J","Lindstrom S","Wrensch M","Moreno V","Klein A","Johansson M","Turman C"],"additional_accession":[]},"is_claimable":false,"name":"Genome-wide analyses characterize shared heritability among cancers and identify novel cancer susceptibility regions.","description":"<h4>Background</h4>The shared inherited genetic contribution to risk of different cancers is not fully known. In this study, we leverage results from 12 cancer genome-wide association studies (GWAS) to quantify pairwise genome-wide genetic correlations across cancers and identify novel cancer susceptibility loci.<h4>Methods</h4>We collected GWAS summary statistics for 12 solid cancers based on 376 759 participants with cancer and 532 864 participants without cancer of European ancestry. The included cancer types were breast, colorectal, endometrial, esophageal, glioma, head and neck, lung, melanoma, ovarian, pancreatic, prostate, and renal cancers. We conducted cross-cancer GWAS and transcriptome-wide association studies to discover novel cancer susceptibility loci. Finally, we assessed th","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Jun","modification":"2026-04-08T18:59:18.139Z","creation":"2025-04-19T21:59:12.32Z"},"accession":"S-EPMC10248849","cross_references":{"pubmed":["36929942"],"doi":["10.1093/jnci/djad043"]}}