{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Mustanski B"],"funding":["NIDA NIH HHS","NIMH NIH HHS"],"pagination":["107134"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10249332"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["127"],"pubmed_abstract":["<h4>Background</h4>Despite evidence that eHealth approaches can be effective in reducing HIV risk, their implementation requirements for public health scale up are not well established, and effective strategies to bring these programs into practice are still unknown. Keep It Up! (KIU!) is an online program proven to reduce HIV risk among young men who have sex with men (YMSM) and ideal candidate to develop and evaluate novel strategies for implementing eHealth HIV prevention programs. KIU! 3.0 is a Type III Hybrid Effectiveness-Implementation cluster randomized trial designed to 1) compare two strategies for implementing KIU!: community-based organizations (CBO) versus centralized direct-to-consumer (DTC) recruitment; 2) examine the effect of strategies and determinants on variability in i"],"journal":["Contemporary clinical trials"],"pubmed_title":["Keep It Up! 3.0: Study protocol for a type III hybrid implementation-effectiveness cluster-randomized trial."],"pmcid":["PMC10249332"],"funding_grant_id":["P30 DA040500","R01 MH118213"],"pubmed_authors":["Savinkina A","Schackman BR","Linas BP","Swann G","Bettin E","Mustanski B","Macapagal K","Dean A","Saber R","Jones JP","Brown CH","Madkins K","Li DH","Janulis P","Marsh E","Benbow N","Smith JD"],"additional_accession":[]},"is_claimable":false,"name":"Keep It Up! 3.0: Study protocol for a type III hybrid implementation-effectiveness cluster-randomized trial.","description":"<h4>Background</h4>Despite evidence that eHealth approaches can be effective in reducing HIV risk, their implementation requirements for public health scale up are not well established, and effective strategies to bring these programs into practice are still unknown. Keep It Up! (KIU!) is an online program proven to reduce HIV risk among young men who have sex with men (YMSM) and ideal candidate to develop and evaluate novel strategies for implementing eHealth HIV prevention programs. KIU! 3.0 is a Type III Hybrid Effectiveness-Implementation cluster randomized trial designed to 1) compare two strategies for implementing KIU!: community-based organizations (CBO) versus centralized direct-to-consumer (DTC) recruitment; 2) examine the effect of strategies and determinants on variability in i","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Apr","modification":"2026-06-02T09:06:27.61Z","creation":"2025-04-05T22:31:14.761Z"},"accession":"S-EPMC10249332","cross_references":{"pubmed":["36842763"],"doi":["10.1016/j.cct.2023.107134"]}}