{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Russell NJ"],"funding":["German Federal Ministry of Health","World Health Organization","Japanese Ministry of Health, Labour and Welfare","Netherlands Ministry of Health, Welfare and Sport","Médecins Sans Frontières","Global Antibiotic Research and Development Partnership","South African Medical Research Council","Luxembourg Ministry of Development Cooperation and Humanitarian Aid","German Federal Ministry of Education and Research","Luxembourg Ministry of Health","LEO Model Foundation","Medical Research Council","Foreign, Commonwealth and Development Office","National Institute for Health Research (NIHR)","Government of the principality of Monaco","The Indian Council for Medical Research","UK Department of Health and Social Care (UK National Institute of Health Research and the Global Antibiotic Resistance Innovation Fund -","Bill and Melinda Gates Foundation","Wellcome Trust","Swiss Federal Office of Public Health"],"pagination":["e1004179"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10249878"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["20(6)"],"pubmed_abstract":["<h4>Background</h4>There is limited data on antibiotic treatment in hospitalized neonates in low- and middle-income countries (LMICs). We aimed to describe patterns of antibiotic use, pathogens, and clinical outcomes, and to develop a severity score predicting mortality in neonatal sepsis to inform future clinical trial design.<h4>Methods and findings</h4>Hospitalized infants <60 days with clinical sepsis were enrolled during 2018 to 2020 by 19 sites in 11 countries (mainly Asia and Africa). Prospective daily observational data was collected on clinical signs, supportive care, antibiotic treatment, microbiology, and 28-day mortality. Two prediction models were developed for (1) 28-day mortality from baseline variables (baseline NeoSep Severity Score); and (2) daily risk of death on IV anti"],"journal":["PLoS medicine"],"pubmed_title":["Patterns of antibiotic use, pathogens, and prediction of mortality in hospitalized neonates and young infants with sepsis: A global neonatal sepsis observational cohort study (NeoOBS)."],"pmcid":["PMC10249878"],"funding_grant_id":["001","MC_UU_00004/05","NIHR200239"],"pubmed_authors":["Zunjie L","Huertas TM","Agarwal R","Chami N","Jarovsky D","Larsson M","Russell NJ","Malhotra-Kumar S","Khorana M","Islam MS","Heath PT","Berkley JA","Berezin EN","Dong H","Nyaoke B","Tusubira V","Adhisivam B","Qazi S","Wang X","Balasegaram M","Wang Y","Bekker A","Glupczynski Y","Ellis S","Saha SK","Saggers R","Roilides E","Bilardi D","Romani L","Chiurchiu S","Stohr W","Cook A","Nakwa F","Ramdin T","Kostyanev T","Walker AS","Yang Y","Feng J","Velaphi S","Ping W","Plakkal N","Mundhra N","Ds M","Qi L","Laoyookhon P","Nardone A","Kontou A","Mussi-Pinhata MM","Chaurasia S","Goel S","Musoke P","Preedisripipat K","Ahmed NU","Ballot D","Ding Y","Riddell A","Thomas R","Carvalheiro CG","Owor M","Bielicki JA","Khavessian N","Roysuwan P","Obiero CW","Dien TM","Dramowski A","Vilken T","Lochindarat S","Mondal N","Dudeja A","Boonkasidecha S","Khan MI","Colas VRF","Cressey TR","Nanavati R","Dung NT","Goossens H","Sharland M","Cousens S","Sarafidis K","Luca M","de Assis ACD","Hao DTH","Nangia S","Nankunda J"],"additional_accession":[]},"is_claimable":false,"name":"Patterns of antibiotic use, pathogens, and prediction of mortality in hospitalized neonates and young infants with sepsis: A global neonatal sepsis observational cohort study (NeoOBS).","description":"<h4>Background</h4>There is limited data on antibiotic treatment in hospitalized neonates in low- and middle-income countries (LMICs). We aimed to describe patterns of antibiotic use, pathogens, and clinical outcomes, and to develop a severity score predicting mortality in neonatal sepsis to inform future clinical trial design.<h4>Methods and findings</h4>Hospitalized infants <60 days with clinical sepsis were enrolled during 2018 to 2020 by 19 sites in 11 countries (mainly Asia and Africa). Prospective daily observational data was collected on clinical signs, supportive care, antibiotic treatment, microbiology, and 28-day mortality. Two prediction models were developed for (1) 28-day mortality from baseline variables (baseline NeoSep Severity Score); and (2) daily risk of death on IV anti","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Jun","modification":"2026-07-15T01:33:22.34Z","creation":"2026-06-27T03:17:06.926Z"},"accession":"S-EPMC10249878","cross_references":{"pubmed":["37289666"],"doi":["10.1371/journal.pmed.1004179"]}}