{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["12(11)"],"submitter":["Awadalla A"],"pubmed_abstract":["<h4>Background</h4>Doxorubicin (DOX) is widely used to treat a variety of malignancies in both adults and children, including those of the bladder, breast, stomach, and ovaries. Despite this, it has been reported to cause hepatotoxicity. The recent discovery of bone marrow-derived mesenchymal stem cells' (BMSCs) therapeutic effects in the context of liver diseases suggests that their administration plays a part in the mitigation and rehabilitation of drug-induced toxicities.<h4>Objectives</h4>This study investigated whether bone BMSCs could reduce DOX-induced liver damage by blocking the Wnt/β-catenin pathway that causes fibrotic liver.<h4>Materials and methods</h4>BMSCs were isolated and treated with hyaluronic acid (HA) for 14 days before injection. Thirty-five mature male SD rats were c"],"journal":["Cells"],"pagination":["1526"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10252276"],"repository":["biostudies-literature"],"pubmed_title":["Hepatoprotective Effects of Hyaluronic Acid-Preconditioned Bone Marrow Mesenchymal Stem Cells against Liver Toxicity via the Inhibition of Apoptosis and the Wnt/β-Catenin Signaling Pathway."],"pmcid":["PMC10252276"],"pubmed_authors":["Elazab KM","El-Sherbiny M","El Nakib AM","Mahmoud SA","Ali M","Hamam ET","Al-Serwi RH","Mostafa SA","Eldesoqui M","Awadalla A","Saleh MA","Ammar OA","Sarhan A"],"additional_accession":[]},"is_claimable":false,"name":"Hepatoprotective Effects of Hyaluronic Acid-Preconditioned Bone Marrow Mesenchymal Stem Cells against Liver Toxicity via the Inhibition of Apoptosis and the Wnt/β-Catenin Signaling Pathway.","description":"<h4>Background</h4>Doxorubicin (DOX) is widely used to treat a variety of malignancies in both adults and children, including those of the bladder, breast, stomach, and ovaries. Despite this, it has been reported to cause hepatotoxicity. The recent discovery of bone marrow-derived mesenchymal stem cells' (BMSCs) therapeutic effects in the context of liver diseases suggests that their administration plays a part in the mitigation and rehabilitation of drug-induced toxicities.<h4>Objectives</h4>This study investigated whether bone BMSCs could reduce DOX-induced liver damage by blocking the Wnt/β-catenin pathway that causes fibrotic liver.<h4>Materials and methods</h4>BMSCs were isolated and treated with hyaluronic acid (HA) for 14 days before injection. Thirty-five mature male SD rats were c","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Jun","modification":"2025-04-05T09:07:09.031Z","creation":"2024-10-19T13:50:11.534Z"},"accession":"S-EPMC10252276","cross_references":{"pubmed":["37296647"],"doi":["10.3390/cells12111526"]}}