{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["12(11)"],"submitter":["Muzes G"],"pubmed_abstract":["The pervasive application of chimeric antigen receptor (CAR)-based cellular therapies in the treatment of oncological diseases has long been recognized. However, CAR T cells can target and eliminate autoreactive cells in autoimmune and immune-mediated diseases. By doing so, they can contribute to an effective and relatively long-lasting remission. In turn, CAR Treg interventions may have a highly effective and durable immunomodulatory effect via a direct or bystander effect, which may have a positive impact on the course and prognosis of autoimmune diseases. CAR-based cellular techniques have a complex theoretical foundation and are difficult to implement in practice, but they have a remarkable capacity to suppress the destructive functions of the immune system. This article provides an ov"],"journal":["Cells"],"pagination":["1534"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10252902"],"repository":["biostudies-literature"],"pubmed_title":["CAR-Based Therapy for Autoimmune Diseases: A Novel Powerful Option."],"pmcid":["PMC10252902"],"pubmed_authors":["Sipos F","Muzes G"],"additional_accession":[]},"is_claimable":false,"name":"CAR-Based Therapy for Autoimmune Diseases: A Novel Powerful Option.","description":"The pervasive application of chimeric antigen receptor (CAR)-based cellular therapies in the treatment of oncological diseases has long been recognized. However, CAR T cells can target and eliminate autoreactive cells in autoimmune and immune-mediated diseases. By doing so, they can contribute to an effective and relatively long-lasting remission. In turn, CAR Treg interventions may have a highly effective and durable immunomodulatory effect via a direct or bystander effect, which may have a positive impact on the course and prognosis of autoimmune diseases. CAR-based cellular techniques have a complex theoretical foundation and are difficult to implement in practice, but they have a remarkable capacity to suppress the destructive functions of the immune system. This article provides an ov","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Jun","modification":"2025-04-04T10:21:17.996Z","creation":"2025-02-19T02:37:54.698Z"},"accession":"S-EPMC10252902","cross_references":{"pubmed":["37296654"],"doi":["10.3390/cells12111534"]}}