biostudies-literatureUnknown12(11)Muzes GThe pervasive application of chimeric antigen receptor (CAR)-based cellular therapies in the treatment of oncological diseases has long been recognized. However, CAR T cells can target and eliminate autoreactive cells in autoimmune and immune-mediated diseases. By doing so, they can contribute to an effective and relatively long-lasting remission. In turn, CAR Treg interventions may have a highly effective and durable immunomodulatory effect via a direct or bystander effect, which may have a positive impact on the course and prognosis of autoimmune diseases. CAR-based cellular techniques have a complex theoretical foundation and are difficult to implement in practice, but they have a remarkable capacity to suppress the destructive functions of the immune system. This article provides an ovCells1534https://www.ebi.ac.uk/biostudies/studies/S-EPMC10252902biostudies-literatureCAR-Based Therapy for Autoimmune Diseases: A Novel Powerful Option.PMC10252902Sipos FMuzes GfalseCAR-Based Therapy for Autoimmune Diseases: A Novel Powerful Option.The pervasive application of chimeric antigen receptor (CAR)-based cellular therapies in the treatment of oncological diseases has long been recognized. However, CAR T cells can target and eliminate autoreactive cells in autoimmune and immune-mediated diseases. By doing so, they can contribute to an effective and relatively long-lasting remission. In turn, CAR Treg interventions may have a highly effective and durable immunomodulatory effect via a direct or bystander effect, which may have a positive impact on the course and prognosis of autoimmune diseases. CAR-based cellular techniques have a complex theoretical foundation and are difficult to implement in practice, but they have a remarkable capacity to suppress the destructive functions of the immune system. This article provides an ov2023-01-01T00:00:00Z2023 Jun2025-04-04T10:21:17.996Z2025-02-19T02:37:54.698ZS-EPMC102529023729665410.3390/cells12111534