{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["11"],"submitter":["Budama-Kilinc Y"],"pubmed_abstract":["<i>Onopordum acanthium</i> is a medicinal plant with many important properties, such as antibacterial, anticancer, and anti-hypotensive properties. Although various studies reported the biological activities of <i>O. acanthium</i>, there is no study on its nano-phyto-drug formulation. The aim of this study is to develop a candidate nano-drug based on phytotherapeutic constituents and evaluate its efficiency <i>in vitro</i> and <i>in silico</i>. In this context, poly (lactic-co-glycolic acid) (PLGA) nanoparticles (NPs) of <i>O. acanthium</i> extract (OAE) were synthesized and characterized. It was determined that the average particle size of OAE-PLGA-NPs was 214.9 ± 6.77 nm, and the zeta potential was -8.03 ± 0.85 mV, and PdI value was 0.064 ± 0.013. The encapsulation efficiency of OAE-PLGA"],"journal":["PeerJ"],"pagination":["e15523"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10257901"],"repository":["biostudies-literature"],"pubmed_title":["<i>In vitro</i> and <i>in silico</i> evaluation of the design of nano-phyto-drug candidate for oral use against <i>Staphylococcus aureus</i>."],"pmcid":["PMC10257901"],"pubmed_authors":["Budama-Kilinc Y","Cetin Aluc C","Gok B","Kecel-Gunduz S"],"additional_accession":[]},"is_claimable":false,"name":"<i>In vitro</i> and <i>in silico</i> evaluation of the design of nano-phyto-drug candidate for oral use against <i>Staphylococcus aureus</i>.","description":"<i>Onopordum acanthium</i> is a medicinal plant with many important properties, such as antibacterial, anticancer, and anti-hypotensive properties. Although various studies reported the biological activities of <i>O. acanthium</i>, there is no study on its nano-phyto-drug formulation. The aim of this study is to develop a candidate nano-drug based on phytotherapeutic constituents and evaluate its efficiency <i>in vitro</i> and <i>in silico</i>. In this context, poly (lactic-co-glycolic acid) (PLGA) nanoparticles (NPs) of <i>O. acanthium</i> extract (OAE) were synthesized and characterized. It was determined that the average particle size of OAE-PLGA-NPs was 214.9 ± 6.77 nm, and the zeta potential was -8.03 ± 0.85 mV, and PdI value was 0.064 ± 0.013. The encapsulation efficiency of OAE-PLGA","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023","modification":"2026-05-28T20:12:55.026Z","creation":"2024-11-19T23:17:25.162Z"},"accession":"S-EPMC10257901","cross_references":{"pubmed":["37309371"],"doi":["10.7717/peerj.15523"]}}