{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["17"],"submitter":["Yang WG"],"pubmed_abstract":["<h4>Background</h4>Artemisinin (ART) is a safe and effective antimalarial drug. In recent years, antimalarial drugs have demonstrated a good therapeutic efficacy in IgA nephropathy, suggesting that this may become a new treatment option.<h4>Purpose</h4>We aimed to evaluate the effect and mechanism of artemisinin in IgA nephropathy.<h4>Methods</h4>In this study, CMap database was used to predict the artemisinin therapeutic effect for IgA nephropathy. A network pharmacology approach was applied to explore the unknown mechanism of artemisinin in IgA nephropathy. We used molecular docking to predict the binding affinity of artemisinin with the targets. A mouse model of IgA nephropathy was established to investigate the therapeutic effect of artemisinin on IgA nephropathy. In vitro, the cell co"],"journal":["Drug design, development and therapy"],"pagination":["1679-1697"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10257916"],"repository":["biostudies-literature"],"pubmed_title":["Exploration of Artemisinin Against IgA Nephropathy via AKT/Nrf2 Pathway by Bioinformatics and Experimental Validation."],"pmcid":["PMC10257916"],"pubmed_authors":["Yang WG","He WJ","Sun A","Liu LL","Liu N","Zhu R"],"additional_accession":[]},"is_claimable":false,"name":"Exploration of Artemisinin Against IgA Nephropathy via AKT/Nrf2 Pathway by Bioinformatics and Experimental Validation.","description":"<h4>Background</h4>Artemisinin (ART) is a safe and effective antimalarial drug. In recent years, antimalarial drugs have demonstrated a good therapeutic efficacy in IgA nephropathy, suggesting that this may become a new treatment option.<h4>Purpose</h4>We aimed to evaluate the effect and mechanism of artemisinin in IgA nephropathy.<h4>Methods</h4>In this study, CMap database was used to predict the artemisinin therapeutic effect for IgA nephropathy. A network pharmacology approach was applied to explore the unknown mechanism of artemisinin in IgA nephropathy. We used molecular docking to predict the binding affinity of artemisinin with the targets. A mouse model of IgA nephropathy was established to investigate the therapeutic effect of artemisinin on IgA nephropathy. In vitro, the cell co","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023","modification":"2025-04-04T10:21:21.932Z","creation":"2025-02-19T02:37:56.818Z"},"accession":"S-EPMC10257916","cross_references":{"pubmed":["37309415"],"doi":["10.2147/DDDT.S403422"]}}